2-Substitutedbenzothiazole derivatives were widely used in chemical, pharmaceutical and agricultural fields. 2-Position functionalized method was a convenient and effective way to synthesize 2-substitutedbenzothiazoles. In this paper, the methods for the synthesis of 2-substitutedbenzothiazoles by the alkylation, acylation, arylation, amination and phosphorylation reactions at the 2-position are reviewed, and their future outlook is also discussed.

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