Abstact:A new Digital Pulse Processing (DPP) module has been developed, based on a domino ring sampler version 4 chip (DRS4), with good time resolution for LaBr 3 detectors, and different digital timing analysis methods for processing the raw detector signals are reported. The module, composed of an eight channel DRS4 chip, was used as the readout electronic and acquisition system to process the output signals from XP20D0 Photomultiplier Tubes (PMTs). Two PMTs were coupled with LaBr 3 scintillator and placed face to face on both sides of a radioactive positron 22 Na source for 511 keV ɤ-ray tests. By analyzing the raw data acquired by the module, the best coincidence timing resolution is about 194.7 ps (FWHM), obtained by the digital constant fraction discrimination (dCFD) method, which is better than other digital methods and analysis methods based on conventional analog systems which have been tested. The results indicate that it is a promising approach to better localize the positron annihilation in positron emission tomography (PET) with time of flight (TOF), as well as for scintillation timing measurement, such as in TOF-ΔE and TOF-E systems for particle identification, with picosecond accuracy timing measurement. Furthermore, this module is more simple and convenient than other systems.