Ruthenium(II)-catalyzed reaction of
N-sulfonylimines with methyl isocyanoacetate proceeds
efficiently under neutral, mild conditions to give
trans-2-imidazolines stereoselectively in high
yields.
2,3-Diamino acids can be easily acquired via the hydrolysis of the
imidazolines in excellent yields.
A possible mechanism for the ruthenium-catalyzed aldol reaction of
the imines under neutral
conditions is discussed.
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