Two novel series of bent-core liquid crystals (9a～9e and 10a～10e) were prepared with a central bent core based on 2,5-disubstitueted-1,3,4-oxadiazole, ester group bridge (coo), alkyl tails with different carbon numbers (n＝5～9), and one side wing substituted by fluorine atom. The structures of the target compounds were confirmed by IR, 1 H NMR, 13 C NMR, MS, and their transition temperatures and phase textures were investigated by using differential scanning calorimetric (DSC) and polarizing optical microscopy (POM). The result suggested that all target compounds had right chemical structure. All compounds 9a～9e and 10a～10e exhibited nematic phase and existed wide temperature range of nematic phase. The widest range of nematic phase was 78 ℃. The temperature range of nematic phase of compounds 9a～9e with lateral monofluoro-substituted benzene was more narrow than compounds 10a～10e with lateral difluoro-substituted benzene. Moreover, compounds 9a～9e showed odd-even effect.