Guanosine (1) as the starting material, reacted with acetic anhydride to obtain 2',3',5'-triO -acetyl-guanosine (2), which reacted with TsCl to obtain 2-amino-6-tosyl-9-(2',3',5'-triO -acetyl-β-D-ribofuranosyl)purine (3). Compound 3 was diazotized with isoamyl nitrite and then reacted with dialkyl disulfides to afford 2-ethylthio-6-tosyl-9-(2',3',5'-triO -acetyl-β-Dribofuranosyl)purine (4). Finally, compounds 5 were acquired by aminolysis and deprotection of 4. Ten new compounds were synthesized and all compounds were characterized with 1 H NMR, 13 C NMR, IR and HRMS. Meanwhile, their antiplatelet aggregation rate was measured. The results show that these compounds have a certain antiplatelet aggregation activity.

No abstract