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The relation between positive cell ratio of HBV related antigen in hepatocytes and the disribution of lymphocyte subpopulation was studied in biopsied liver of the chronic hepatits B patients. In case both Po-L3/T8 and Pa-T8/T1 were high rate, HBc antigen positive rate was high, view of intensive inflammation were observed in parenchyma and ALT showed the tendency to be high. These results indicate that in case of liver cell injury on hepatitis B virus, Po-L3/T8 reacts to HBc antigen in liver cell and participates in the change of Pa-T8/T1 simultaneously.

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