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Adsorption of the new generation antiepileptic drug E Keppra® dry syrup containing 50％ levetiracetam to an automated dividing and packing machine was observed after dispensing by using the machine. We examined drug loss and variation in divided weight after dispensing a pediatric dose of the dry syrup. When 1.4 g of E Keppra® dry syrup 50％ was divided into 14 packs using an automated dividing and packing machine, the drug loss per pack was 10％ -27 ％. The high drug loss was observed during an early stage of packaging the dry syrup. Conversely, drug loss per pack was less than 10％ when 7.0 g of the dry syrup was divided into 14 packs. The variation in divided weight in 1.4 g of the dry syrup was 2.3％, which was larger than the variation in 7.0 g of the dry syrup. The drug loss and variation in divided weight were observed under the following conditions: the dry syrup particles were less than the average particle diameter of 150 μm and the humidity was less than 50％. The drug loss during division was prevented by addition of a vehicle, such as lactose, to the dry syrup. These results indicate that using the machine to divide the E Keppra® dry syrup 50％ into low doses recommended for children gives rise to inaccurate dosing.

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増田富士雄 1＊ ・服部 昇 2 ・石田志朗 3 Supercritical-flow sedimentary structures of fluvial deposits in the Plio-Pleistocene Katata Formation, Kobiwako Group, Japan Fujio Masuda 1＊ , Noboru Hattori 2 and Shiro Ishida 3Sedimentary structures related to supercritical-flows, including antidunes, chutes-and-pools and cyclic steps, have been identified from fluvial flood deposits in the Plio-Pleistocene Katata Formation, Kobiwako Group, Shiga, Japan. The characteristics of sedimentary structures by high-energy flood flows are 1) backset laminae and backstepping lamina sets with up-stream migration, 2) sigmoidal, wavy and HCS-mimics laminae, 3) scour and fill gravel, sand and mud, 4) cyclically scoured erosional bases, and 5) mixed beds with heterolithic and well and poorly sorted deposits. The observed sedimentary structures considered as supercritical-flow deposits have high diversity. The deposits with much mud-content show fast sedimentation rate from the supercritical-flows contained large amount of suspended mud. We have to observe furthermore the sedimentary structures linked to supercritical-flow bedforms from deposits of various ages, areas and depositional environments.