Background.Hepatocellular carcinoma (HCC) remains a major cause of cancer-related deaths worldwide, with limited treatment options. Long noncoding RNAs (lncRNAs) are essential regulators of HCC progressand are closely related to the pyroptotic cell death. However, the influence of pyroptosis-related lncRNAs on HCC remains indefinite. Methods. We systematically explored the expression profile of pyroptosis-related lncRNAs to establish a novel signature for predicting the outcome of HCC patients based on The Cancer Genome Atlas (TCGA) database by multiple analysis methods. Four lncRNAs with the highest hazard ratio in the above model were selected for external verification in the Gene Expression Omnibus (GEO) database. Finally, the expression of these lncRNAs was verified by real-time quantitative polymerase chain reaction (RT-qPCR) in different cell lines. Results. The results showed that 25 pyroptosis-related lncRNAs were evidently correlatedwith the prognosis of HCC patients. Cox regression analyses demonstrated the prognostic ability of the risk model established by the pyroptosis-related lncRNAs. And the high and low-risk groups were linked to different types of infiltrating immune cells and affected the physiological state of the tumor microenvironment in HCC. Conclusion.We constructed and validated an independent pyroptosis-related lncRNAs prognostic model and preliminarily described the potential immune correlations, providing novel prognostic factors and directions of immunotherapeutic strategies for HCC.