No abstract

Digitaria sanguinalis)、稗草(Echinochloa crus-galli)、狗尾草(Setaria viridis)等均具有 100%的除草活性, 进一步活性筛 选发现, (R)-(＋)-N-[(2-氯噻唑-5-基)甲氧基]-O-[4-((6-氯喹喔啉-2-基)氧基)苯氧基]乳酸酰胺(2f)除草活性(马唐 IC 50 ＝6.8 g/ha, 稗草 IC 50 ＝6.6 g/ha)远高于同类商品化除草剂炔草酯和先导化合物 A8169.

A series of 1,3-thiazine derivatives 1a～1p were designed and synthesized by the reaction of aromatic aldehyde via condensation and cyclization, and their inhibitory activity of nueraminidase (NA) and serotonin reuptake (SERT) were evaluated in vitro. The pharmacological results showed that compound 1i exhibits good activity of NA with the inhibitory rate of 68.91% at the concentration of 40 μg/mL, which is similar to oseltamivir (inhibitory rate is 72.6%), moreover, at the concentration of 10.0 μg/mL, compounds 1d, 1e and 1f exhibit good serotonin reuptake inhibitory activity with inhibitory rates of 99.5%, 99.6% and 99.8%, respectively.