This paper reports a novel intermolecular addition and free radical homolytic reaction for the synthesis of (E)-3-aryloxyacrylate derivatives from alkynoates and phenols using N,N-dimethylformamide (DMF) as the solvent and CuO/CH 3 ONa as the system of promotion. The structures of product were confirmed by IR, 1 H NMR, 13 C NMR and elemental analysis. The results showed that this synthetic route had the advantages of easy-obtained raw materials, simple work-up and high purity product. Keywords alkynoates; phenols; intermolecular addition; (E)-3-aryloxyacrylates为典型反应, 考察了 反应时间、反应温度、溶剂、催化剂和碱的种类和用量 等方面对 3aa 产率的影响, 实验结果如表 1 所示. 从表 1 的数据可知, 在以甲苯、乙腈、1,2-二氯乙烷、1,4-二氧 六环作为溶剂的条件下, 该模型反应不发生(表 1, Entries 1～4). 而当该反应在 100 ℃的条件下进行时, 以 N,N-二甲基甲酰胺(DMF)为溶剂时, 反应 4 h 能以 25% 的收率得到目标化合物 3aa. 接下来, 我们考察了不同 碱对该反应的影响, 研究发现甲醇钠和乙醇钠是比较理

This paper reports a simple intermolecular condensation reaction for the synthesis of 1,4-dihydropyridine derivatives from acetoacetanilides using AcOH as the solvent and ammonium persulfate [(NH 4 ) 2 S 2 O 4 ] as the oxidant. The structures of products were confirmed by IR, 1 H NMR, 13 C NMR and HR-MS. In addition, a possible reaction mechanism was proposed.