Ihe synthesis of phosphorylated AchynmUres bidentota pdysaccbaride (P-AbPS) wss reported based on Merent strategies.obtained when phosphorus oxycbloride (PO(&) was used as a phosphorylating agent and trimethyl phosphate-pyridine or dimethyl formamide wss used as solvent. The hhences of different solvents and d o n conditions were discussed . The pharmmlogv assay shorn that P-AhPS postses antitumor activity against sarcoma 180 and Lewis lung cancer in mice. The P-AbFS With l&h d m of s u b s t i w o n (D.S. > 0.5) WBS