연구의 필요성대한대장항문학회는Purpose: This study aimed to investigate nutritional risk, physical activity, and quality of life (QoL) and the interaction of these factors in colorectal cancer patients. Methods: Participants were colorectal cancer patients receiving follow-up treatment at the colorectal cancer outpatient clinic of Severance Hospital in Seoul. Participants were recruited from October 25 to November 30, 2010. The survey questionnaire consisted of Nutritional Risk Score (NRS), International Physical Activity Questionnaire (IPAQ) and Functional Assessment of Cancer Therapy -scales for Colorectal Cancer (FACT-C). Results: NRSs were significantly higher in patients with low BMI (F = 18.63, p< .001) and those who were underwent colorectal surgery within 1 month (F = 5.96, p < .001). Physical activity level of the participants was 28.96METs. Lower nutritional risk was associated with a higher QoL (r = -.34, p < .001). In a multiple regression analysis, the predictors of QoL were the age, economic status, and nutritional risk of the patient (R 2 = 40.0%). Conclusions: Targeted tailored nursing interventions are needed to assess nutritional risks in order to improve colorectal cancer patients' QoL.

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Background : Neoadjuvant chemotherapy has become a standard therapy for patients with locally advanced breast cancer. Recently, new regimens of breast cancer chemotherapy containing taxanges further improve survival compared with standard chemotherapy regimens, but taxanes are toxic, expensive,and might benefit only a few patients. However, predictive factors in breast cancer treated with neoadjuvant chemotherapy differ from those of early breast cancer. The purpose of this study was to identify the clinical significance of potential predictive factors in breast cancer patients treated by neoadjuvant chemotherapy.Methods : A total of 112 stage II and III breast cancer patients received neoadjuvant docetaxel/doxorubicin chemotherapy were enrolled in this study. We examined the clinical and biological factors by immunohistochemistry. We analyzed clinical outcome and their correlation with clinicopathologic parameters.Results : A total of 112 patients with a median age of 45.9 were evaluated in this study. The overall clinical response rate(RR) was 80(71.5%) including 5(4.5%) complete response and 75(67.0%) partial response.Consequently, 12 (10.6%) patients achieved a pCR. Among the traditional clinicopathologic parameters(age, stage, histologic grade, ER, PR, c-erbB2, p53 and Ki-67) investigated, none of the marker was correlated with response rate(RR). However, pCR was correlated with initial tumor stage(p=.004), triple negative(p=.002), p53(p=.011), .Conclusions : Several molecular markers provided useful predictive information in locally advanced breast cancer patients treated with neoadjuvant chemotherapy. Triple negative phenotype, p53 high expression and Ki-67 high expression was associated with a higher pCR to neoadjuvant docetaxel/doxorubicin chemotherapy.

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