The purpose of this study was to investigate the correlation between regular mealtime, oral health knowledge and oral health to prevent dental impairment of college students. This research design is correlation study. Data of 903 were collected from June 1 to June 30, 2010. Data were analyzed using the SPSS PASW Statistics 18.0 Program. More than 50% of respondents were the irregular mealtime. Higher percentage of correct answer in the oral health knowledge showed periodontal disease prevention(82.6%). There were a statistical significant in grade, major, smoking, drinking, and wishing for dental care between general characteristics and regular mealtime respectively(p<.05). Between general characteristics and oral health knowledge were a statistical significant in gender, age, grade, smoking, and dental checkup respectively(p<.05). On the other hand, there was a statistical significant wishing for dental care between general characteristics and oral health(p<.001). Regular mealtime was negatively associated with oral health(p<.01). Education for oral health should include regular mealtime, prohibit of smoking and alcohol, right toothbrushing and so on.