0243 Corticotropin Releasing Factor in the Amygdala Regulates Individual Differences in Rem Responses to Stress

Abstract

Introduction:To date, no validated, computer-based tools exist to measure, predict, and optimize neurobehavioral performance due to sleep loss at both individual and group-average levels, while also accounting for the effects of caffeine. We addressed this gap by developing and validating a predictive mathematical model of performance [the unified model of performance (UMP)], and instantiating it into two tools: 1) 2B-Alert App, a smartphone application for real-time, individualized performance prediction and 2) 2B-Alert Web, a Webbased software for designing sleep/wake and caffeine schedules to optimize group-average performance. Methods: We developed and validated the UMP on psychomotor vigilance task (PVT) performance data from 14 different studies (in laboratory and field conditions), encompassing >500 subjects and including a wide range of sleep/wake schedules and caffeine doses. We then developed and validated an automated method to customize the UMP to an individual's sleep-loss phenotype based on the individual's PVT measurements. Finally, we embedded these capabilities into a smartphone app (Android and iPhone) and a Web tool, which allow users to enter sleep/wake schedules and caffeine consumption (doses and times), and obtain individual-specific or group-average performance predictions. Results: The UMP predicted group-average PVT performance across 26 different sleep/wake schedules (from partial to total sleep loss) and 6 different caffeine doses (ranging from repeated 200 mg doses to single 600 mg dose) with errors ranging from 6% to 36%. Accounting for the effects of caffeine in the model improved prediction accuracy by up to 70%. Individualized UMP models improved prediction accuracy by up to 50% compared to a group-average model. The Web tool is freely available at: <https://2b-alert-web.bhsai.org>, and the 2B-Alert App is expected to be available by summer of 2017. Conclusion: The 2B-Alert App and Web provide practical means for personal fatigue management and for optimizing work/rest schedules.