0509 the Maudsley Early Onset Schizophrenia Study: Predictors of Psychosocial Outcome at a 4-Year Follow-Up

Vyas, Nora S.; Vourdas, Apostolos; Byrne, Patricia; Frangou, Sophia

doi:10.1016/s0920-9964(06)70480-7

Cited by 40 publications

(57 citation statements)

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“…A total of 402 papers were identified by the search strategy, from which we identified 28 non-overlapping first episode studies that met inclusion criteria (see Appendix 1) (Montague et al, 1989;Barnes et al, 2000;Craig et al, 2000;de Haan et al, 2000;Drake et al, 2000;Ho et al, 2000;Larsen et al, 2000;Black et al, 2001;Verdoux et al, 2001;Cullberg et al, 2002;Malla et al, 2003;Addington et al, 2004;Sim et al, 2004;Chen et al, 2005;Harris et al, 2005;Manchanda et al, 2005;Melle et al, 2005;Oosthuizen et al, 2005;Petersen et al, 2005;Wade et al, 2005;Clarke et al, 2006;Ucok et al, 2006;Wunderink et al, 2006;Crespo-Facorro et al, 2007;Malla et al, 2007;Vyas et al, 2007;Gorna et al, 2008;Yamazawa et al, 2008). The selected studies included a total of 3998 participants.…”

Section: Studies and Patientsmentioning

confidence: 99%

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Boonstra

Klaassen

Sytema

et al. 2012

Schizophrenia Research

211

134

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Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Background: Longer duration of untreated psychosis (DUP) is associated with poorer outcome in terms of positive symptoms, relapse rate, and time to remission. In contrast, the association with negative symptoms is less consistent. Aims: The study had three aims. First, to arrive at a more precise estimate of the correlation between DUP and negative symptoms than previous reviews, by substantially increasing the amount of available data. Second, to see whether the strength of this correlation attenuated over longer follow-up intervals. Third, to determine whether there is a relationship between DUP and changes in negative symptoms. Method: Relevant databases were searched for studies published between December 1992 and March 2009 that reported data on DUP and negative symptoms. We obtained individual patient data where possible and calculated summary correlations between DUP and negative symptoms for each study at baseline, short and long-term follow-up. We used multilevel regression analysis to examine whether the effect of DUP on negative symptoms was the greatest in the early stages of illness. Results: We included 28 non-overlapping studies from the 402 papers detected by the search strategy. After contacting the authors we obtained individual patient data from 16 of these studies involving 3339 participants. The mean DUP was 61.4 weeks (SD = 132.7, median DUP = 12.0). Shorter DUP was significantly associated with less severe negative symptoms at baseline and also at short (1-2 years) and longer term follow-up (5-8 years) (r = 0.117, 0.180 and 0.202 respectively, p b 0.001). The relationship between improvement in negative symptoms and DUP was found to be non-linear: people with a DUP shorter than 9 months showed substantially greater negative symptom reduction than those with a DUP of greater than 9 months. Conclusions: Shorter DUP is associated with less severe negative symptoms at short and long-term follow up, especially when the DUP is less than 9 months. Since there is no effective treatment for negative symptoms, reducing DUP to less than 9 months may be the best way to ameliorate them.

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Section: Studies and Patientsmentioning

confidence: 99%

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Boonstra

Klaassen

Sytema

et al. 2012

Schizophrenia Research

211

134

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“…It afflicts almost 1% of the world's population, is the seventh most costly medical illness in our society (10), and ranks ninth in global burden of illness (11,12). Schizophrenia typically has an onset in late adolescence or early adulthood and is characterized by positive and negative symptomatology together with defects of psychosocial and cognitive functioning (13). The clinical diagnosis is based on the DSM-IV-TR of the American Psychiatric Association (14), which requires patients to present with core symptoms for at least 1 month.…”

Section: Overview Of Schizophreniamentioning

confidence: 99%

Positron Emission Tomography in Schizophrenia: A New Perspective

Patel¹,

Vyas²,

Puri³

et al. 2010

J Nucl Med

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PET is an important functional imaging technique that can be used to investigate neurotransmitter receptors and transporters directly by mapping human brain function. PET is increasingly being used greatly to advance our understanding of the neurobiology and pathophysiology of schizophrenia. Methods: This review focuses on the use of PET tracers and kinetic modeling in identifying regional brain abnormalities and regions associated with cognitive functioning in schizophrenia. A variety of PET tracers have been used to identify brain abnormalities, including 11 C, 15 O-water, 18 F-fallypride, and L-3,4-dihydroxy-6-18 F-fluorophenylalanine ( 18 F-FDOPA). Results: Some studies have used compartmental modeling to determine tracer binding kinetics. The most consistent findings show a difference in the dopamine content in the prefrontal cortex, anterior cingulate gyrus, and hippocampus between healthy controls and patients with schizophrenia. Studies also show a higher density of D 2 receptors in the striatum and neural brain dysconnectivity. Conclusion: Future investigations integrating clinical, imaging, genetic, and cognitive aspects are warranted to gain a better understanding of the pathophysiology of this disorder.

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“…EOS is associated with greater disease severity [21][22][23][24], developmental delays [25][26][27][28], higher rates of chromosomal abnormalities and greater burden of copy number variants [29][30][31][32][33], and poor prognosis [34][35][36] compared with the adult onset counterpart.…”

Section: Children and Adolescents With Schizophreniamentioning

confidence: 99%

Theory of Mind in the Early Course of Schizophrenia

Vyas

et al. 2017

CPSR

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Theory of mind deficit is a core feature of schizophrenia and is considered a vulnerability marker of the disorder. The majority of studies measuring theory of mind in schizophrenia involve multiple-episode or chronic schizophrenia patients, and therefore it is important to delineate whether these deficits occur before or following illness-onset by assessing high-risk subjects (clinical high risk and ultra-high risk), early-onset psychosis, and first-degree relatives. We address the question of whether theory of mind impairment is specific or a facet of general cognitive impairment in these clinical populations, and incorporate genetic and neuroimaging studies on theory of mind. The review provides a succinct evaluation of the literature, discusses current limitations and proposes future directions.

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0509 the Maudsley Early Onset Schizophrenia Study: Predictors of Psychosocial Outcome at a 4-Year Follow-Up

Cited by 40 publications

References 0 publications

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Duration of untreated psychosis and negative symptoms — A systematic review and meta-analysis of individual patient data

Positron Emission Tomography in Schizophrenia: A New Perspective

Theory of Mind in the Early Course of Schizophrenia

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