1-(2-Fluorophenyl)-6,7-dimethoxyisochroman

Abstract

In the title compound, C17H17FO3, the benzene ring of the isochroman unit is inclined at 84.96 (7)° to the fluoro­benzene ring plane, and the pyran ring adopts a half-boat conformation. In the crystal structure, C—H⋯O hydrogen bonds link mol­ecules into rows along the c axis, while C—H⋯O inter­actions and C—H⋯F hydrogen bonds to the fluorine acceptor stack the mol­ecules down the b axis. In addition, the crystal structure exhibits a weak C—H⋯π inter­action between a methyl H atom of the meth­oxy group and the dimethoxy­benzene ring of an adjacent mol­ecule.

Synthesis of Oxacycles Employing the Oxa‐Pictet–Spengler Reaction: Recent Developments and New Prospects

“…The reaction in water shows several advantages such as short reaction times, high yields, inexpensive catalyst, lack of side-product formation and minimum work up require- 21 3-NO 2 80 56 [b] [a] Crystallographic data of this isochroman derivative have been published. [59]…”