1,3-Disubstituted Thioureas: Versatile Building Blocks for the Construction of Heterocycles

Abstract

This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research 1,3-Disubstituted Thioureas: Versatile Building Blocks for the Construction of Heterocycles Compiled by Harisadhan Ghosh Harisadhan Ghosh was born in Burdwan, West Bengal, India, in 1983. He received his B.Sc. (2004) and M. Sc. (2006) degrees in Organic Chemistry from Visva-Bharati University, Santiniketan, India. Currently he is carrying out his Ph.D thesis under the supervision of Prof. Bhisma K. Patel as a CSIR junior research fellow. His research interests focus on hypervalent iodine mediated organic synthesis.

Quantum chemical studies on molecular structure, spectroscopic (IR, Raman, UV–Vis), NBO and Homo–Lumo analysis of 1-benzyl-3-(2-furoyl) thiourea

“…Thiourea (NH 2 CSNH 2 ) derivates are very useful building blocks for the synthesis of a wide range of aliphatic macromolecular and heterocyclic compounds [1][2][3]. These compounds could be used as ligand to form complexes with different transition metals [4][5][6][7][8][9][10].…”

Structural, vibrational and electronic characterization of 1-benzyl-3-furoyl-1-phenylthiourea: an experimental and theoretical study

“…Electrochemical sensors based in aroylthioureas as ionophores have been successfully developed and some basic approaches to describe the interaction mechanism of the ionophore with the heavy metal ions have been investigated [5][6][7][8]. Thiourea compounds are very useful building blocks for the synthesis of a wide range of aliphatic macromolecular and heterocyclic compounds [9][10][11]. These compounds are remarkable chelating agents for analytical chemistry and a variety of metal complexes have been described in literature [12][13][14][15][16][17][18].…”

“…[5][6][7][8] Thiourea compounds are very useful building blocks for the synthesis of a wide range of aliphatic macromolecular and heterocyclic compounds. [9][10][11] These compounds are remarkable chelating agents in analytical chemistry and a variety of metal complexes have been described in the literature. [12][13][14][15][16][17][18] The presence of hard and soft donor sites in these compounds offers a huge bonding potential since both carbonyl and thiocarbonyl groups can coordinate metallic ions in a different manner.…”

The Synthesis and Antimicrobial Properties of New 2-(R-Phenylimino)-1,3-thiazoline Derivatives Containing the N-Methylpiperazine Moiety

“…Unsymmetric thioureas can be synthesized from amines. By the reaction of amines with carbon disulfide in ethanol reflux the symmetrical 1,3-disubstituted thioureas can be easily obtained [14], while the unsymmetric thioureas are obtained by the reaction of amines with isothiocyanates [15][16][17][18]. Isothiocyanates are obtained from amines by the interaction of triethylamine with different reagents, such as [bis(acetoxy)iodo]benzene or dithiocarbamates [19] in acetonitrile, dithiocarbamates and lead nitrate solution [20] or iodine [21]; carbon disulfide and tosyl chloride [22].…”