1,4-Dihydropyridine derivatives as deactivators of singlet oxygen

Tirzit, G. D.; Byteva, I. M.; Salokhiddinov, K. I.; Gurinovich, G. P.; Dubur, G. Ya.

doi:10.1007/bf00506035

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…[43][44][45][46][47] Previously, Tirzit et al demonstrated ARA for 1,4-DHP derivatives, 26 as well as revealed their singlet oxygen quenching activity, similar to that of a-tocopherol. 48 Particularly dihydropyridine derivatives are known to be oxidized to appropriate pyridine derivatives; in the case of 1,4-dihydronicotinamide (as part of redox coenzymes NAD-H or NADP-H) reciprocal hydrogen transfer occurs. Additionally some of the dihydropyridine derivatives act as electron and hydrogen donors to oxidants, activated unsaturated compounds, free radicals, reactive oxygen species, reactive nitrogen species, so antiradical and antioxidant properties of DHP derivatives have been discovered.…”

Section: Antiradical Activity Of 14-dhp Amphiphilesmentioning

confidence: 99%

Gene delivery agents possessing antiradical activity: self-assembling cationic amphiphilic 1,4-dihydropyridine derivatives

et al. 2013

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Section: Antiradical Activity Of 14-dhp Amphiphilesmentioning

confidence: 99%

Gene delivery agents possessing antiradical activity: self-assembling cationic amphiphilic 1,4-dihydropyridine derivatives

et al. 2013

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“…The above-mentioned experiments show that, in the presence of substrate 1a , traditional quenchers DPBF and DABCO captured a large amount of singlet oxygen, resulting in the formation of a trace amount of 2a . Although some 1,4-dihydropyridine derivatives can be used as deactivators for singlet oxygen, the quenching effect of traditional singlet oxygen quenchers is much higher than that of substrate 1a .…”

mentioning

confidence: 99%

Photocatalyst-Free Singlet Oxygen-Induced Oxygenation: A Strategy for the Preparation of 5-Cyano-2-pyridones Driven by Blue-Light Irradiation

Zhang

Lan

et al. 2020

J. Org. Chem.

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A mild, catalyst- and metal-free photochemical protocol for the oxygenation of 3-cyano-1,4-dihydropyridines to 5-cyano-2-pyridones was developed. Utilizing molecular oxygen from the air as the oxidant and a cheap blue LED lamp as the light source, a variety of 3-cyano-1,4-dihydropyridines were converted into the corresponding 5-cyano-2-pyridones in moderate to excellent yields. Exploration of the substrate scope revealed that 3-cyano and 4-aryl groups play an important role in the formation of 2-pyridone.

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“…Tirzit et al [ 242 ] have observed quenching of singlet oxygen by DHPs. This observation paved the ground for further research related to reactions of DHPs with hydroxyl radicals (Tirzit et al [ 243 ]), singlet oxygen (Kazush et al [ 94 ]), and mechanisms of action.…”

Section: 14-dihydropyridines: a Separate Group Of Bioantioxidantsmentioning

confidence: 99%

1,4‐Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

Velēna

Žarković

Trošelj

et al. 2016

Oxidative Medicine and Cellular Longevity

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Many 1,4-dihydropyridines (DHPs) possess redox properties. In this review DHPs are surveyed as protectors against oxidative stress (OS) and related disorders, considering the DHPs as specific group of potential antioxidants with bioprotective capacities. They have several peculiarities related to antioxidant activity (AOA). Several commercially available calcium antagonist, 1,4-DHP drugs, their metabolites, and calcium agonists were shown to express AOA. Synthesis, hydrogen donor properties, AOA, and methods and approaches used to reveal biological activities of various groups of 1,4-DHPs are presented. Examples of DHPs antioxidant activities and protective effects of DHPs against OS induced damage in low density lipoproteins (LDL), mitochondria, microsomes, isolated cells, and cell cultures are highlighted. Comparison of the AOA of different DHPs and other antioxidants is also given. According to the data presented, the DHPs might be considered as bellwether among synthetic compounds targeting OS and potential pharmacological model compounds targeting oxidative stress important for medicinal chemistry.

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1,4-Dihydropyridine derivatives as deactivators of singlet oxygen

Cited by 5 publications

References 6 publications

Gene delivery agents possessing antiradical activity: self-assembling cationic amphiphilic 1,4-dihydropyridine derivatives

Gene delivery agents possessing antiradical activity: self-assembling cationic amphiphilic 1,4-dihydropyridine derivatives

Photocatalyst-Free Singlet Oxygen-Induced Oxygenation: A Strategy for the Preparation of 5-Cyano-2-pyridones Driven by Blue-Light Irradiation

1,4‐Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

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