1-Deoxynojirimycin improves high fat diet-induced nonalcoholic steatohepatitis by restoring gut dysbiosis

Zheng, Junping; Zhu, Lin; Hu, Baifei; Zou, Xiaojuan; Hu, Haiming; Zhang, Zhigang; Jiang, Nan; Ma, Jun; Yang, Huabing; Liu, Hongtao

doi:10.1016/j.jnutbio.2019.05.013

Cited by 27 publications

(12 citation statements)

References 44 publications

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“…Analysis of the fecal microbiota demonstrated that PCFM attenuated gut microbiota dysbiosis induced by diabetes. Among these genera altered by PCFM supplementation, Lachnospiraceae_UCG-006 was found to be enriched in HFD-fed mice [ 49 ], which was consistent with the significantly high relative abundance of Lachnospiraceae_UCG-006 in the MC group of our study. Lachnospiraceae_UCG-006 was also reported to be positively correlated with lipid-related indicators (i.e., TG, total cholesterol (TC), high-density liptein cholesterol (HDL-C) and low-density lipoprotein (LDL-C)) [ 49 ].…”

Section: Discussionsupporting

confidence: 87%

“…Among these genera altered by PCFM supplementation, Lachnospiraceae_UCG-006 was found to be enriched in HFD-fed mice [ 49 ], which was consistent with the significantly high relative abundance of Lachnospiraceae_UCG-006 in the MC group of our study. Lachnospiraceae_UCG-006 was also reported to be positively correlated with lipid-related indicators (i.e., TG, total cholesterol (TC), high-density liptein cholesterol (HDL-C) and low-density lipoprotein (LDL-C)) [ 49 ]. Therefore, the beneficial effect of PCFM administration on serum and liver TG accumulation reduction may be associated with the decreased relative abundance of the Lachnospiraceae_UCG-006 in PCFM group.…”

Section: Discussionsupporting

confidence: 87%

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Hypoglycemic Effect of Prolamin from Cooked Foxtail Millet (Setaria italic) on Streptozotocin-Induced Diabetic Mice

Yin

Liu

et al. 2020

Nutrients

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Millet proteins have been demonstrated to possess glucose-lowering and lipid metabolic disorder modulation functions against diabetes; however, the molecular mechanisms underlying their anti-diabetic effects remain unclear. The present study aimed to investigate the hypoglycemic effect of prolamin from cooked foxtail millet (PCFM) on type 2 diabetic mice, and explore the gut microbiota and serum metabolic profile changes that are associated with diabetes attenuation by PCFM. Our diabetes model was established using a high-fat diet combined with streptozotocin before PCFM or saline was daily administrated by gavage for 5 weeks. The results showed that PCFM ameliorated glucose metabolism disorders associated with type 2 diabetes. Furthermore, the effects of PCFM administration on gut microbiota and serum metabolome were investigated. 16S rRNA gene sequencing analysis indicated that PCFM alleviated diabetes-related gut microbiota dysbiosis in mice. Additionally, the serum metabolomics analysis revealed that the metabolite levels disturbed by diabetes were partly altered by PCFM. Notably, the decreased D-Glucose level caused by PCFM suggested that its anti-diabetic potential can be associated with the activation of glycolysis and the inhibition of gluconeogenesis, starch and sucrose metabolism and galactose metabolism. In addition, the increased serotonin level caused by PCFM may stimulate insulin secretion by pancreatic β-cells, which contributed to its hypoglycemic effect. Taken together, our research demonstrated that the modulation of gut microbiota composition and the serum metabolomics profile was associated with the anti-diabetic effect of PCFM.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

Hypoglycemic Effect of Prolamin from Cooked Foxtail Millet (Setaria italic) on Streptozotocin-Induced Diabetic Mice

Yin

Liu

et al. 2020

Nutrients

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“…Recently, several investigations have reported that DNJ or DNJ-enriched mulberry leaf extracts markedly altered gut microbial community to improve metabolic diseases by promoting the growth of Akkermansia spp. and SCFA-producing genera such as Bifidobacterium , Lactobacillus , and Alistipes ( 24 , 38 , 39 ). In particular, DNJ was reported to enrich the abundance of Akkermansia spp.…”

Section: Discussionmentioning

confidence: 99%

The Gut Microbiota-Produced Indole-3-Propionic Acid Confers the Antihyperlipidemic Effect of Mulberry-Derived 1-Deoxynojirimycin

Zhang

et al. 2020

mSystems

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Hyperlipidemia has been intensively focused on by researchers around the world owing to its major contribution to cardiovascular diseases. Various evidence reveals that women are more susceptible than male counterparts to dyslipidemia, making sex-dependent therapeutic strategies and drugs urgently needed. In the present work, we demonstrate that DNJ, the main active component of mulberry leaves, exerts an obvious female-preferential antihyperlipidemic effect through specifically enriching Akkermansia and Clostridium XIVa and elevating an active microbial metabolite, indole-3-propionic acid (IPA), in female mice. Moreover, we have corroborated the potent lipid-lowering efficacy of IPA both in vitro and in vivo. These findings not only indicate a potential mechanism by which gut microbes and their metabolites confer the beneficial role of DNJ in ameliorating hyperlipidemia but also provide an in-depth theoretical basis for therapeutic exploitation of DNJ as a female-specific intervention against hyperlipidemia.

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“…Compared with the NC group, HFD increased the abundance of Lachnospiraceae_UCG-006 ( Figure 6(c) ), which is consistent with a previous study [ 54 ]. A previous study in mice also demonstrated that HFD caused the elevated abundance of Lachnospiraceae_UCG-006 and further showed that the deteriorated lipid profiles were positively correlated with the abundance of Lachnospiraceae_UCG-006 [ 55 ]. In mice, HFD was found to increase the abundance of Lactococcus , and Lactococcus was reported to be positively correlated with serum dyslipidemia [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

The Beneficial Effects of Edible Kynurenic Acid from Marine Horseshoe Crab (Tachypleus tridentatus) on Obesity, Hyperlipidemia, and Gut Microbiota in High‐Fat Diet‐Fed Mice

Zhang

Yang

et al. 2021

Oxidative Medicine and Cellular Longevity

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The marine horseshoe crab (Tachypleus tridentatus) has been considered as food and traditional medicine for many years. Kynurenic acid (KA) was isolated from horseshoe crab in this study for the first time in the world. A previous study in 2018 reported that intraperitoneal administration of KA prevented high-fat diet- (HFD-) induced body weight gain. Now, we investigated the effects of intragastric gavage of KA on HFD mice and found that KA (5 mg/kg/day) inhibited both the body weight gain and the increase of average daily energy intake. KA reduced serum triglyceride and increased serum high-density lipoprotein cholesterol. KA inhibited HFD-induced the increases of serum low-density lipoprotein cholesterol, coronary artery risk index, and atherosclerosis index. KA also suppressed HFD-induced the increase of the ratio of Firmicutes to Bacteroidetes (two dominant gut microbial phyla). KA partially reversed HFD-induced the changes in the composition of gut microbial genera. These overall effects of KA on HFD mice were similar to that of simvastatin (positive control). But the effects of 1.25 mg/kg/day KA on HFD-caused hyperlipidemia were similar to the effects of 5 mg/kg/day simvastatin. The pattern of relative abundance in 40 key genera of gut microbiota from KA group was closer to that from the normal group than that from the simvastatin group. In addition, our in vitro results showed the potential antioxidant activity of KA, which suggests that the improvement effects of KA on HFD mice may be partially associated with antioxidant activity of KA. Our findings demonstrate the potential role of KA as a functional food ingredient for the treatment of obesity and hyperlipidemia as well as the modulation of gut microbiota.

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1-Deoxynojirimycin improves high fat diet-induced nonalcoholic steatohepatitis by restoring gut dysbiosis

Cited by 27 publications

References 44 publications

Hypoglycemic Effect of Prolamin from Cooked Foxtail Millet (Setaria italic) on Streptozotocin-Induced Diabetic Mice

Hypoglycemic Effect of Prolamin from Cooked Foxtail Millet (Setaria italic) on Streptozotocin-Induced Diabetic Mice

The Gut Microbiota-Produced Indole-3-Propionic Acid Confers the Antihyperlipidemic Effect of Mulberry-Derived 1-Deoxynojirimycin

The Beneficial Effects of Edible Kynurenic Acid from Marine Horseshoe Crab (Tachypleus tridentatus) on Obesity, Hyperlipidemia, and Gut Microbiota in High‐Fat Diet‐Fed Mice

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