1-h Postprandial glucose level is related to the serum anti-Müllerian hormone level in women with polycystic ovary syndrome

Abstract

The aim of this study was to evaluate the relationship between the serum anti-Müllerian hormone (AMH) level and parameters related to insulin resistance in Korean women with polycystic ovary syndrome (PCOS). A total of 95 Korean women aged 18-33 years who were newly diagnosed with PCOS according to the Rotterdam Consensus at a university hospital were included in this study. Blood samples were collected from all participants during the early follicular phase using tubes without anticoagulants after an overnight fasting to determine the serum AMH level and other biochemical parameters, and then a standard 2-h 75-g oral glucose tolerance test (OGTT) was performed for all participants. All patients with PCOS were divided into two groups based on the serum AMH level: group 1 (AMH < 10.0 ng/ml) and group 2 (AMH ≥ 10.0 ng/ml). The clinical variables were not significantly different between the two groups. The mean postprandial glucose level at 1 h (PPG1) in group 1 (111.70 ± 4.9 mg/dl) was significantly lower than that in group 2 (136.76 ± 9.86 mg/dl). No significant differences between the two groups were found in the other insulin resistance-related parameters. In conclusion, the serum AMH level may be related to PPG1 in women with PCOS.

Association between serum gonadotropin level and insulin resistance-related parameters in Korean women with polycystic ovary syndrome

“…In the current study, we categorized all participants into three groups according to the LH/FSH ratio: group 1 (LH/FSH ratio <1.0), group 2 (1.0≤ LH/FSH ratio <2.0), and group 3 (LH/FSH ratio ≥2.0). In this study, participants with higher LH/FSH ratios showed higher total antral follicle counts and larger total ovarian volume, and these findings are in agreement with those of previous studies [1516222324]. …”

“…Inappropriate gonadotropin secretion is one of the most characteristic hormonal features and is associated with the continuation of the anovulatory state in women with PCOS [15]. The abnormal gonadotropin secretion pattern in PCOS is characterized by increased serum LH levels and an increased LH/FSH ratio [4], and this pattern is related to increases in both the amplitude and frequency of LH secretion secondary to increased pulse frequency of hypothalamic gonadotropin-releasing hormone [819].…”

“…Plasma glucose concentrations peak ~60 minutes after the start of a meal in the non-diabetic population [30]. Recently, PPG1 has been regarded as a strong predictor of the future risk of T2DM comparable to PPG2 [153132], and Abdul-Ghani et al [31] even suggested that PPG1 may be more useful as a predictor of the future development of T2DM compared to fasting glucose or PPG2. QUICKI has recently become known as an accurate and useful parameter for evaluating insulin resistance [3334].…”

“…The small sample size prevented us from performing subgroup analysis according to the different phenotypic subgroups of study participants with PCOS. In addition, as described in a previous study of ours [15], we did not assess the postprandial serum insulin levels at 1 and 2 hours, and we only assessed the fasting insulin level.…”

“…A number of studies have investigated the association between serum anti-Müllerian hormone level and insulin resistance-related parameters [12131415]; however, to date, few studies have evaluated the association between serum LH level and insulin resistance with respect to PCOS [1617]. Moreover, to the best of our knowledge no studies have assessed the relationship between serum gonadotropin level and postprandial glucose level at 1 hour (PPG1).…”