1% topical cidofovir used as last alternative to treat viral infections

Recalcitrant warts and topical cidofovir: predictive factors of good response

“…Topical cidofovir could be considered a useful therapeutic option for the management of warts that are recalcitrant to usual therapies. 5,6 We can recommend, regarding at our results, cidofovir 3% cream twice daily with occlusion for a period of about 12 weeks at least to check if there is response or not; specially in female patients and those younger than 15 years. 7 If within this time there is no reduction in the size or number of PW it might be advisable to suspend the treatment due to lack of efficacy.…”

Topical cidofovir for viral warts in children

“…Many cases of mucocutaneous viral infections treated with topical cidofovir at different concentrations have been reported in adults 8,9 . In addition, a clinical phase I/II trial of HIV‐infected adults with genital warts treated topically with different concentrations (0.1–3%) of cidofovir found better results with 3%.…”

“…Cidofovir is a powerful nucleoside analogue of deoxycitidine monophosphate with antiviral activity against a broad range of DNA viruses 2 . Although its approved indication is for intravenous treatment of cytomegalovirus retinitis in AIDS, it has recently been used to treat skin infections caused by papillomavirus 1–9 . It has been used topically, 1–4,6–9 intralesionally and intravenously 5 although few cases have been reported in children 1–7 …”

Successful Treatment of Acyclovir-Resistant Herpes Simplex Virus With Intralesional Cidofovir

“…There is a precedent for using topical cidofovir, 1% and 3%, in dermatology for cutaneous HSV,5 human papillomavirus,6 and molluscum contagiosum 7. Intravenous cidofovir is also used in patients with acyclovir-resistant HSV skin disease 8,9.…”