10- or 30-minute treadmill exercise rescues motor behaviors through inhibiting apoptosis in a rat MCAo model

Abstract

Materials and Methods AnimalsAll experiments were approved by the Institutional Animal Care and Use Committee at Chonnam National University Medical School. Every effort to alleviate the pain of animals was made. A total of 24 male Sprague-Dawley rats (280 -320 g, 8 weeks old) were purchased from Damul Science (Daejeon, Korea) and randomly assigned to four groups using a random table method: shamsurgery and sedentary group (sham, n = 6), ischemia and sedentary group (MCAo, n = 6), ischemia and 10-minutes exercise group (MCAo + 10Exe, n = 6), and ischemia and 30-minute exercise group (MCAo + 30Exe, n = 6). The rats were habituated under a 12-hour light/dark cycle at