1002 Pulse Cyclophosphamide Therapy for Steroid-Resistant Focal Segmental Glomerulosclerosis in Children

Abstract

β-Thalassemia minor is a common heterozygous hemoglobinopathy that is characterized by both microcytosis and hypochromia. It has been postulated that low grade hemolysis, tubular iron deposition and toxins derived from erythrocytes might cause renal tubular damage in adult patients with β-thalassemia minor. The aim of this study is to investigate the renal tulbar function in children with β-thalassemia minor and to determine its possible harmful effects. Methods: The study was conducted on 50 children (22 male and 28 female) at the age of years (range 4-19 years) with β-Thalassemia minor. A control group was formed with 50 healthy children whose ages and sexes match those in the first group. Blood and 24-hour urine samples were obtained for hematologic and biochemical analysis. Results: There was statistically significant difference among the two groups in terms of the results of FE UA (%) , TPR (%) , FE k (%) , GFR , Urine uric Acid , serum Mg (P < 0/05). But other significant signs of renal tubulopathy such as hypercalciuria , and tubular proteinuria (β 2-microglobolinuria) were not seen. Conclusion: On the contrary of children with β-Thalassemia major , renal tubular dysfunction is not common in children with β-Thalassemia minor. .Alsow it suggested that in future studies to confirm renal tubular disfanction should be considered specific test such as NAG measurement and specific parameter of oxidative stress such as urin zinc level (indirect evidence of oxidative stress).