1026 Regional observational study of missed cases of neonatal early-onset sepsis associated with the use of the SRC compared to NICE CG149

Abstract

Table 1 Factors associated with toxic vancomycin levels in neonates in Epoch 1 and Epoch 2Conclusion There is a high incidence of toxic vancomycin levels in preterm babies on NICU. Risk is predicted by duration of vancomycin exposure and potentially birthweight, GA and PDA presence. Our dosing changes did not reduce the number of babies with vancomycin toxicity but may have reduced the impact on renal function.