106. Novel Subventricular Zone Early Progenitor Cell Specific Adenovirus for In Situ Brain Stem Cell Bioengineering Unveils Cellular Heterogeneity

Abstract

Neural stem/progenitor cells (NSPC) have the potential to selfrenew and to generate all neural lineages as well as to repopulate damaged areas in the brain. Our recent endeavors in the generation of Ad vectors that specifically target SPC in situ have focused on linking selective peptides to viral particles that direct the vector to yet unknown receptors on the surface of stem cells. Using an Ad-PEGylation approach, we demonstrated that a short artificial