11β Hydroxysteroid dehydrogenase type 2 and dietary acid load are independently associated with blood pressure in healthy children and adolescents

Abstract

A lower 11βHSD2 activity and higher dietary acid load may independently contribute to higher systolic BP in healthy children.

Dietary acid load and cardiometabolic risk factors: a systematic review and meta-analysis of observational studies

“…1, 522 records were accessed by searching the scientific databases of which 316 records remained after removing the 206 duplicate references. After exclusion of irrelevant studies, sixteen cohort studies (6,13,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and seventeen cross-sectional studies (1,11,12,(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) were included in the current systematic review. Characteristics of the included studies, which were published between 2005 and 2017, are shown in Table 1.…”

“…The sample size of these studies ranged from sixty-three to 92 478 individuals, and totally just 3574 individuals were aged 17 years or younger. Of thirty-three included studies, eleven were conducted in the Asia (1,11,12,22,25,27,30,37,38,41) , fourteen in Europe (6,13,17,20,21,23,24,26,29,31,32,34,36,43) and eight in the USA (18,19,28,33,35,39,42,44) . Four studies were done on men (13,17,33,43) , five on women (12,18,21,23,32) and the remaining studies implied on both genders.…”

“…DAL had been assessed by NAE method in six studies (17,20,26,28,34,44) , PRAL in nineteen (1,6,(11)(12)(13)20,21,23,25,27,(29)(30)(31)(36)(37)(38)40,41,43) and NEAP in nine studies (18,19,22,24,32,33,35,39,42) . These assessment methods were assessed and calculated using FFQ (6,11,18,(22)(23)(24)(25)27,(29)(30)(31)(32)37,44) , 24 h urine collection (17,19,26,…”

“…These assessment methods were assessed and calculated using FFQ (6,11,18,(22)(23)(24)(25)27,(29)(30)(31)(32)37,44) , 24 h urine collection (17,19,26,28,33,34) , diet history questionnaire (1,12,21,38,40) , 24 h food recall (35,39,41,44) , 3 d dietary record (36,42) and 7 d dietary record (13,20,43) . Included studies had assessed weight (26,27,37) , BMI (1,6,11-13,17-19,21-26, 28-33,35,37-44) , WC (11,12,37,41) , TC (6,11,12,34,41) , HDL-C (6,12,27,…”

11β-hydroxysteroid dehydrogenase type-II activity is affected by grapefruit juice and intense muscular work

“…This enzyme oxidizes cortisol (F) into inactive cortisone (E), thereby rendering the mineralocorticoid receptor-hormone complex inactive (1). The enzymatic activity of 11β-HSD2 can be estimated using the ratios of these hormones in urine (2)(3)(4)(5) and saliva (Sal) fluids (4,6,7). Subtle deficiencies in 11β-HSD2 activity have been reported in subsets of hypertensives and normotensives (8,9), whereas more severe hypertension and hypokalemia are observed in cases of substantial or complete loss of 11β-HSD2 activity (1,9).…”