12-P003 Gata2 is a postmitotic selector gene for GABAergic neurons in the midbrain

Abstract

Vertebrate neurotrophins (NTs: NGF, BDNF, NT3, NT4) form a family of signalling molecules with key functions in nervous system development and function. They regulate cell survival, axon guidance and targeting, synaptic formation and function, learning and memory. Deficient NGF function occurs in Alzheimer's disease and alterations in BDNF function underlie psychiatric and cognitive disorders such as epilepsy, autism, anxiety and depression. NTs are therapeutic targets in pain control (e.g. chronic pain in cancer). We recently reported that a family of Drosophila neurotrophins (DNTs) formed by DNT1, DNT2 and Spz regulate neuronal survival and targeting in fruit-flies (Zhu et al., 2008 PLoS Biology 6,

GATA2 is required for lymphatic vessel valve development and maintenance

“…Although important for neural (38,39) and urogenital (40) development, GATA2 has been most extensively studied in hematopoiesis, where it plays several key roles. GATA2 is crucial for hematopoietic stem cell development during both embryogenesis and adulthood (41)(42)(43), and in hematopoietic progenitor cells; it acts combinatorially within jci.org Volume 125 Number 8 August 2015…”

Unsupervised tensor decomposition-based method to extract candidate transcription factors as histone modification bookmarks in post-mitotic transcriptional reactivation

“…Other than these five TF families reported in the original study (Kang et al, 2020), the TFs detected most frequently within seven TF-related categories in Enrichr were as follows (Table 9): GATA2 (Kala et al, 2009), ESR1 (Kato and Ogawa, 1994), TCF21 (Kim et al, 2017), TP53 (Ha et al, 2007), WT1 (Shandilya and Roberts, 2015), NFE2L2 (also known as NRF2 (Martin-Hurtado et al, 2019)), GATA1 (Kadauke et al, 2012), and GATA3 (Shafer et al, 2017). All of these TFs have been reported to be related to mitosis directly or indirectly, in addition to JUN and JUND, which are listed in Table 6.…”

Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space

“…In hematopoietic and adipose progenitors, Gata2 is involved in maintaining the cells in an undifferentiated state, and overexpression of Gata2 promotes cell cycle progression and inhibits differentiation (Tsai et al, 2005;Lugus et al, 2007). In the central nervous system, Gata2 is required to specify the progenitors to serotonergic fate in rhombomere 1 and to GABAergic fate in midbrain (Craven et al, 2004;Kala et al, 2009). In addition, loss of Gata2 in midbrain leads to a complete fate switch of GABAergic neural progenitors to glutamatergic fate, whereas it did not affect the proliferation of progenitors in this region (Kala et al, 2009).…”

“…In the central nervous system, Gata2 is required to specify the progenitors to serotonergic fate in rhombomere 1 and to GABAergic fate in midbrain (Craven et al, 2004;Kala et al, 2009). In addition, loss of Gata2 in midbrain leads to a complete fate switch of GABAergic neural progenitors to glutamatergic fate, whereas it did not affect the proliferation of progenitors in this region (Kala et al, 2009). On the other hand, in caudal hindbrain and spinal cord, Gata2 expression inhibits proliferation and forces cycling neural progenitors to a quiescent and differentiating state by interfering with cell cycle regulators and Notch pathway (El Wakil et al, 2006).…”