12 Years’ Experience with Intraoperative Radiotherapy (IORT) of Malignant Gliomas

Abstract

IORT has been shown to be feasible; perioperative complication rates were not increased. Survival was generally not improved compared to a historical control group. Recurrences achieved the same survival as primary tumors, and GBM also had a slightly increased survival, thus being possible indications for IORT.

Effect of Carbogen Breathing on the Radiation Response of a Human Glioblastoma Xenograft

“…Intrinsic radioresistance can be counteracted by increasing the total tumor dose, by using for instance, radiosurgery or stereotactic radiotherapy which is, however, limited to smaller tumors [34] or by combining radiotherapy with 2-deoxy-d-glucose [42]. Intraoperative radiotherapy also resulted in a slightly improved survival in GBM [39]. Another way to optimize efficacy of irradiation is to improve oxygenation.…”

Radiotherapy for brain tumors – New techniques and treatment strategies

“…The advantage of the IORT is the earlier radiation treatment with a higher single dose to an exact defined area. Like HDRbrachytherapy, the IORT is passed only in single specialized centers [25] .…”

9 years tumor free survival after resection, intraoperative radiotherapy (IORT) and whole brain radiotherapy of a solitary brain metastasis of non-small cell lung cancer

“…One to three metastases of a suitable size (5/4 cm) may be an indication for stereotactic radiosurgery [4,5]. Electron beam intraoperative radiotherapy (IORT) for patients with malignant brain tumors has been performed at our institution since May 1992 [6]. Only few patients with brain metastases have been treated so far.…”

“…No macroscopic residual tumor was left. IORT was carried out at a nondedicated facility with 14 MeV electrons from a linear accelerator using a 5 cm round cone [6]. The applied IORT dose was 20 Gy relative to the 90% isodose.…”