13-Deoxyitol A, a new insecticidal isoryanodane diterpene from the seeds of Itoa orientalis

Tang, Wenwei; Wei, Xiaoyi; Xu, Hanhong; Zeng, Dongqiang; Liang, Liping

doi:10.1016/j.fitote.2009.03.006

Cited by 21 publications

(20 citation statements)

References 7 publications

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“…Besides clerodane-type diterpenes, Tang et al [ 108 ] reported that isoryanodane-type diterpenes (compounds 56 and 57 , Figure 24 ) showed antifeedant activity against various insect pests, and, according to the authors, the hydroxyl group at the C-14 position play an important role in their antifeedant activity.…”

Section: Toxicity Of Diterpenesmentioning

confidence: 99%

An Overview of Biotransformation and Toxicity of Diterpenes

2018

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Diterpenes have been identified as active compounds in several medicinal plants showing remarkable biological activities, and some isolated diterpenes are produced at commercial scale to be used as medicines, food additives, in the synthesis of fragrances, or in agriculture. There is great interest in developing methods to obtain derivatives of these compounds, and biotransformation processes are interesting tools for the structural modification of natural products with complex chemical structures. Biotransformation processes also have a crucial role in drug development and/or optimization. The understanding of the metabolic pathways for both phase I and II biotransformation of new drug candidates is mandatory for toxicity and efficacy evaluation and part of preclinical studies. This review presents an overview of biotransformation processes of diterpenes carried out by microorganisms, plant cell cultures, animal and human liver microsomes, and rats, chickens, and swine in vivo and highlights the main enzymatic reactions involved in these processes and the role of diterpenes that may be effectively exploited by other fields.

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Section: Toxicity Of Diterpenesmentioning

confidence: 99%

An Overview of Biotransformation and Toxicity of Diterpenes

2018

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“…Natural products derived from plants and microorganisms have been used for insect control [6]. Azadirachtin, a natural compound isolated from neem Azadirachta indica , is considered superior over other compounds since it has wide range of biological activities.…”

Section: Introductionmentioning

confidence: 99%

Antifeedant, larvicidal and growth inhibitory bioactivities of novel polyketide metabolite isolated from Streptomyces sp. AP-123 against Helicoverpa armigera and Spodoptera litura

Arasu

Al-Dhabi

Saritha³

et al. 2013

BMC Microbiol

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BackgroundConsiderable attention has been paid to actinomycetes, especially the secondary metabolites obtained from Streptomyces species, as the best alternatives to chemicals as biological control agents for polyphagous pests such as Helicoverpa armigera and Spodoptera litura. On the basis of their novel biocontrol attributes, novel polyketide metabolite isolated from marine Streptomyces sp. AP-123 exhibited significant antifeedant, larvicidal and growth inhibitory activities against polyphagous pests.ResultsLeaf disc no-choice method was used for the insect bioassay. The polyketide metabolite presented significant antifeedant activities against H. armigera (78.51%) and S. litura (70.75%) at 1000 ppm concentration. The metabolite also exhibited high larvicidal activities against H. armigera (63.11%) and S. litura (58.22%) and the LC50 values were 645.25 ppm for H. armigera and 806.54 ppm for S. litura. The metabolite also prolonged the larval–pupal duration of the insects at all the tested concentrations.ConclusionsThe activities of the polyketide metabolite were concentration dependent for both the insects therefore it could be used as an agent to prepare new pesticidal formulations.

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“…Some other properties, such as antifeedant (Tang et al ., ), antitoxin (Moura et al ., ), antiallergic (Cheenpracha et al ., ) and antiasthmatic (Cho et al ., ), antifouling (Reina et al ., ), and antiangiogenic activity (Wang et al ., ), have also been reported with diterpenes. Chemical structures of some important diterpenes are shown in Fig.…”

Section: A Revision On Diterpenesmentioning

confidence: 99%

Therapeutic Potential of Essential Oils Focusing on Diterpenes

et al. 2016

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Among all plant derivates, essential oils (EOs) have gained the attention of many scientists. Diterpenes, a family of components present in some EO, are becoming a milestone in the EOs world. The goal of this review is to describe a scenario of diterpenes taking into health-consumption deportment. Previous studies revealed that diterpenes have antioxidant, antimicrobial, antiviral, antiprotozoal, cytotoxic, anticancer, antigenotoxic, antimutagenic, chemopreventive, antiinflammatory, antinociceptive, immunostimulatory, organoprotective, antidiabetic, lipid-lowering, antiallergic, antiplatelet, antithrombotic, and antitoxin activities. In conclusion, diterpenes may be an immense featuring concern in pharmaceutical consumption from a drug discovery point of view. Copyright © 2016 John Wiley & Sons, Ltd.

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13-Deoxyitol A, a new insecticidal isoryanodane diterpene from the seeds of Itoa orientalis

Cited by 21 publications

References 7 publications

An Overview of Biotransformation and Toxicity of Diterpenes

An Overview of Biotransformation and Toxicity of Diterpenes

Antifeedant, larvicidal and growth inhibitory bioactivities of novel polyketide metabolite isolated from Streptomyces sp. AP-123 against Helicoverpa armigera and Spodoptera litura

Therapeutic Potential of Essential Oils Focusing on Diterpenes

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