13th Workshop consensus for vitamin D nutritional guidelines

Norman, Anthony W.; Bouillon, Roger; Whiting, Susan J.; Vieth, Reinhold; Lips, P.

doi:10.1016/j.jsbmb.2006.12.071

Cited by 195 publications

(121 citation statements)

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“…However, Heaney (5) maintains that insufficiency of vitamin D occurs in the range of 13 to 32 ng/mL, values at which serum parathyroid hormone (PTH) continues to be upregulated and calcium absorption is compromised. The starting level of insufficiency for serum vitamin D25(OH) is a point of contention in the literature (5)(6)(7)(8)(9). The assignment of a consistent serum vitamin D25(OH) level across laboratories is lacking but typically ranges from 10 to 20 ng/mL (10).…”

Section: Introductionmentioning

confidence: 99%

Influence of Season, Ethnicity, and Chronicity on Vitamin D Deficiency in Traumatic Spinal Cord Injury

Oleson

Patel

Wuermser

2010

The Journal of Spinal Cord Medicine

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Background: Inadequate levels of vitamin D increase the risk of osteoporosis, a highly prevalent condition in patients with traumatic spinal cord injury (SCI). Reduced sunlight and dark skin further contribute to low vitamin D levels. Objectives: To compare serum 25-hydroxy vitamin D [vitamin D25(OH)] levels in acute and chronic SCI and to explore seasonal and ethnic differences among patients with acute and chronic SCI. Patients/Methods: Patients (N 5 96) aged 19 to 55 years with C3-T10 motor complete SCI participated. Acute SCI was 2 to 6 months after injury, whereas chronic SCI was at least 1 year from injury. Serum vitamin D25(OH), calcium, and parathyroid hormone were drawn during summer or winter months. Vitamin D deficiency (,13 ng/mL), insufficiency (,20 ng/mL), and subtherapeutic (,32 ng/mL) levels were compared for all groups. A 3-way analysis of covariance was adopted to determine significant main effects of season, chronicity, and ethnicity. Interactions between season and chronicity, season and ethnicity, and chronicity and ethnicity were evaluated. Evaluation of a 3-way interaction among season, chronicity, and ethnicity was completed. Results: In summer, 65% of patients with acute SCI and 81% of patients with chronic SCI had subtherapeutic vitamin D levels, whereas in winter, 84% with acute SCI and 96% with chronic SCI had vitamin D25(OH) (,32ng/mL). Lower vitamin D25(OH) levels were observed in African Americans relative to whites. Significant main effects were noted for season (P 5 0.017), chronicity (P 5 0.003), and ethnicity (P , 0.001). However, interactions between 2 or more factors were not found. Conclusions: Vitamin D insufficiency and deficiency are found in the majority of patients with chronic SCI and in many with acute SCI. Initial screening for serum vitamin D25(OH) levels should be performed early in rehabilitation. Periodic monitoring in the chronic setting is highly recommended.

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Section: Introductionmentioning

confidence: 99%

Influence of Season, Ethnicity, and Chronicity on Vitamin D Deficiency in Traumatic Spinal Cord Injury

Oleson

Patel

Wuermser

2010

The Journal of Spinal Cord Medicine

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“…Nonetheless, there is expert consensus that 25-hydroxyvitamin D should be greater than 50 nmol/L (20 ng/mL) in all individuals [33,42], although some experts advocate a mean population value of 75 nmol/L (30 ng/L) or greater [11]. However, with the combined analysis of bone mineralization and vitamin D status, we conclude minimum levels of more than 75 nmol/L (30 ng/mL) can guarantee at least skeletal health.…”

Section: Discussionmentioning

confidence: 99%

“…According to Norman et al [33], 50% of the elderly living in North America and Western Europe and probably 2 .…”

Section: Discussionmentioning

confidence: 99%

How Much Vitamin D Do We Need for Skeletal Health?

Domarus

Brown

Barvencik

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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Background Vitamin D is critical for musculoskeletal health and has been implicated in the risk of extraskeletal diseases, including cancer, cardiovascular diseases, and autoimmune diseases, as well as overall mortality. Although numerous studies deal and have dealt with vitamin D deficiency and its consequences, experts cannot agree on the right 25-hydroxyvitamin D levels. This survey aims to shed light on the ongoing vitamin D controversy from different angles. Questions/purposes We discuss the minimum threshold for the 25-hydroxyvitamin D level to guarantee optimal health, why vitamin is D critical to musculoskeletal and extraskeletal functions, and new evidence for the success of prevention measures such as food fortification. Methods We searched PubMed, Google Scholar, and reference lists of articles using several keywords. The most recent search was in February 2011. Results While the use of parathyroid hormone as a surrogate measure did not lead to a consensus concerning the required 25-hydroxyvitamin D serum level, the combined analysis of bone mineralization and vitamin D status has established minimum levels of more than 75 nmol/L (30 ng/mL) to guarantee at least skeletal health. An effective measure to approach this status is food fortification, which has been demonstrated by countries such as Canada, the United States, and Finland. Conclusions Given the health economic implications of failure to maintain a balanced vitamin D status, action is recommended to integrate current scientific knowledge on vitamin D into physicians' treatment of patients and governmental policies on food fortification.

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“…In view of the new parameters for interpretation of vitamin D status outlined previously, the 13 th Workshop on Vitamin D concluded that vitamin D insufficiency was a global epidemic 177 . Nevertheless, it is also clear that some groups are much more at risk of vitamin D insufficiency than others, and prominent amongst these are pregnant women.…”

Section: Vitamin D-insufficiency and Pregnancymentioning

confidence: 99%

Vitamin D and Human Pregnancy

Grayson¹,

Hewison

2011

Fet. Matern. Med. Rev.

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At the end of 2007, Time magazine listed the “benefits of vitamin D” as one of its top 10 medical breakthroughs for that year. Since then there has been a remarkable upsurge of interest in vitamin D, with new research advances seemingly published on a weekly basis. In particular, there has been increasing awareness of the variability of vitamin D status in populations across the globe and, significantly, a growing debate about the need for revised parameters for vitamin D supplementation. Although sub-optimal vitamin D is likely to be a widespread problem for 21stcentury societies, it is also clear that some groups are at much greater risk of low vitamin D status. Prominent amongst these are pregnant women and the aim of the following review article will be to discuss this problem in further detail with specific emphasis on its potential physiological and clinical impact.

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13th Workshop consensus for vitamin D nutritional guidelines

Cited by 195 publications

References 0 publications

Influence of Season, Ethnicity, and Chronicity on Vitamin D Deficiency in Traumatic Spinal Cord Injury

Influence of Season, Ethnicity, and Chronicity on Vitamin D Deficiency in Traumatic Spinal Cord Injury

How Much Vitamin D Do We Need for Skeletal Health?

Vitamin D and Human Pregnancy

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