16. Single-cell RNA Sequencing in Mice Identifies Downregulation of Fra2-jun Signaling in Treatment of Radiation-induced Fibrosis by Fat Grafting

Abstract

Agrin-NP/NHC treatment in vivo promotes neuromuscular junction reinnervation and improves functional recovery of forelimb grip strength. Our group has previously established the benefits of insulin-like growth factor 1 (IGF-1) nanoparticles on ameliorating the effects of chronic denervation. Future studies will combine Agrin-NPs and IGF-1-NPs and evaluate their hypothesized synergistic benefits.