16S rDNA‐based metagenomic analysis of dental plaque and lung bacteria in patients with severe acute exacerbations of chronic obstructive pulmonary disease

Abstract

These results support the hypothesis that dental bacteria may contribute to the pathology of severe AE-COPD.

Periodontitis: from microbial immune subversion to systemic inflammation

“…Polymicrobial infections including the opportunistic pathogen Pseudomonas aeruginosa are associated with exacerbations of COPD increasing its morbidity and mortality 23,146 . P. gingivalis is readily detected with P. aeruginosa in tracheal aspirates of patients with acute COPD exacerbations 24 and can enhance the pathogenicity of P. aeruginosa in the context of lower airway infection 147,148 . Indeed, P. gingivalis promotes the ability of P. aeruginosa to invade respiratory epithelial cells and modulates its apoptosis-inducing capacity 147,148 .…”

Comparison Study of Oropharyngeal Microbiota in Case of Bronchial Asthma and Chronic Obstructive Pulmonary Disease in Different Severity Levels

“…Aggregatibacter segnis также относится к условно-патогенным микроорганизмам, вызывающим периодонтит [21]. Связь Aggregatibacter segnis с БА установлена впервые, однако из-вестно, что периодонтопатогенные бактерии играют роль в патогенезе ХОБЛ [22], что также показано нами далее. Интересен факт более выраженного присутствия этого микроорганизма у больных с тяжелой БА по сравнению с легкой формой, что несколько приближает состав микро-биоты тяжелой БА к ХОБЛ.…”

“…Об-суждается возможность существования в ротовой полости пула условно-патогенных бактерий, которые могут иметь значение в патогенезе респираторных расстройств [35]. В ряде исследований отмечается связь между курением, наличием ХОБЛ и периодонтита.…”

16S rDNA analysis of periodontal plaque in chronic obstructive pulmonary disease and periodontitis patients

“…Third, lower airway microbiota was not sampled in this study. Although the microbiota in periodontal tissue can immigrate into lower airway tracts and some dominant pathogenic bacteria were detected both in periodontal pocket and tracheal aspirate [15], to what extent the periodontal bacteria is associated with that in lower airway is less understood. Lower airway microbiota was the most optimal and direct way to study the microbiota related to COPD.…”

“…The statistical association between periodontitis and COPD has been clinically established [5,6], but less is known regarding how they are associated and their underlying mechanisms. In a previous study, some specific bacteria including Klebsiella pneumonia , Pseudomonas aeruginosa , Streptococcus pneumoniae , Porphyromonas gingivalis , Treponema denticola , and Tannerella forsythia were more abundant in both tracheal aspirate and periodontal pockets in severe acute exacerbations of COPD patients, suggesting particular bacteria were related to acute exacerbations of COPD [15]. …”