1713c Epigenetics in solvent induced neurobehavioral disorders

Abstract

chronic solvent encephalopathy, characterised by persistent neurocognitive symptoms, often leading to early retirement. Surprisingly, under detection of CSE occurs even in targeted health screens by occupational health services. The non-specific cognitive findings are challenging to interpret for clinicians and thus the improvement of protocols for the neuropsychological assessment are necessary. Not all exposed develop neurological dysfunction, does epigenetics reveal why neurobehavioural disorders develop. And finally, the question is addressed, does occupational solvent exposure increase the risk of neurodegenerative disease, such as Parkinson disease.