17q12-21 and asthma: interactions with early-life environmental exposures

Blekić, Mario; Bukvić, Blaženka Kljaić; Aberle, Neda; Marinho, Susana; Hankinson, Jenny; Čustović, Adnan; Simpson, Angela

doi:10.1016/j.anai.2013.01.021

Cited by 36 publications

(31 citation statements)

References 40 publications

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“…A previous study from the Tucson cohort (with measurements of lung function available at ages 4 wk and 6 yr) suggested that for persistent wheezers the deficit in lung function is not present soon after birth, but is acquired by age 6 years, whereas children with transient early wheeze have diminished lung function shortly after birth (22). Although we are unable to investigate lung function in infancy in our analysis, we have shown a deficit in sRaw by age 3 years in those with transient and persistent wheeze (but not late-onset wheeze).…”

Section: Discussionmentioning

confidence: 99%

“…Genetic factors also have an important role; for example, we have recently reported significant associations between genetic variants in VEGF-A with lung function (including sRaw) measured during childhood, with the effect persisting into adulthood (21). Gene-by-environment interactions may also play a role in the developmental pathway of lung function (22). These studies have laid important foundations for the understanding of the physiologic, genetic, and environmental factors associated with diminished lung function.…”

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confidence: 99%

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Trajectories of Lung Function during Childhood

Belgrave

Buchan

Bishop

et al. 2014

Am J Respir Crit Care Med

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163

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Rationale: Developmental patterns of lung function during childhood may have major implications for our understanding of the pathogenesis of respiratory disease throughout life.Objectives: To explore longitudinal trajectories of lung function during childhood and factors associated with lung function decline.Methods: In a population-based birth cohort, specific airway resistance (sRaw) was assessed at age 3 (n = 560), 5 (n = 829), 8 (n = 786), and 11 years (n = 644). Based on prospective data (questionnaires, skin tests, IgE), children were assigned to wheeze phenotypes (no wheezing, transient, late-onset, and persistent) and atopy phenotypes (no atopy, dust mite, non-dust mite, multiple early, and multiple late). We used longitudinal linear mixed models to determine predictors of change in sRaw over time.Measurements and Main Results: Contrary to the assumption that sRaw is independent of age and sex, boys had higher sRaw than girls (mean difference, 0.080; 95% confidence interval [CI], 0.049-0.111; P , 0.001) and a higher rate of increase over time. For girls, sRaw increased by 0.017 kPa $ s 21 per year (95% CI, 0.011-0.023). In boys this increase was significantly greater (P = 0.012; mean betweensex difference, 0.011 kPa $ s 21; 95% CI, 0.003-0.019). Children with persistent wheeze (but not other wheeze phenotypes) had a significantly greater rate of deterioration in sRaw over time compared with never wheezers (P = 0.009). Similarly, children with multiple early, but not other atopy phenotypes had significantly poorer lung function than those without atopy (mean difference, 0.116 kPa $ s 21 ; 95% CI, 0.065-0.168; P , 0.001). sRaw increased progressively with the increasing number of asthma exacerbations.Conclusions: Children with persistent wheeze, frequent asthma exacerbations, and multiple early atopy have diminished lung function throughout childhood, and are at risk of a progressive loss of lung function from age 3 to 11 years. These effects are more marked in boys.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Trajectories of Lung Function during Childhood

Belgrave

Buchan

Bishop

et al. 2014

Am J Respir Crit Care Med

Self Cite

163

140

View full text Add to dashboard Cite

show abstract

“…A child’s susceptibility to asthma is likely to be determined by interacting genetic and environmental factors [3,4]. Ownership of household pets has attracted attention as an early-life environmental exposure which might play a role in the development of asthma and allergy.…”

Section: Introductionmentioning

confidence: 99%

Associations of Pet Ownership with Wheezing and Lung Function in Childhood: Findings from a UK Birth Cohort

et al. 2015

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BackgroundAsthma is a heterogeneous condition and differential effects of pet ownership on non-atopic versus atopic asthma have been reported. The aim of this study was to investigate whether pet ownership during pregnancy and early childhood was associated with wheezing from birth to age 7 years and with lung function at age 8 years in a UK population-based birth cohort.MethodsData from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to investigate associations of pet ownership at six time-points from pregnancy to age 7 years with concurrent episodes of wheezing, wheezing trajectories (phenotypes) and lung function at age 8 years using logistic regression models adjusted for child’s sex, maternal history of asthma/atopy, maternal smoking during pregnancy, and family adversity.Results4,706 children had complete data on pet ownership and wheezing. From birth to age 7 years, cat ownership was associated with an overall 6% lower odds of wheezing (OR=0.94 (0.89-0.99)). Rabbit and rodent ownership was associated with 21% (OR=1.21 (1.12-1.31)) and 11% (OR=1.11 (1.02–1.21)) higher odds of wheezing, respectively, with strongest effects evident during infancy. Rabbit and rodent ownership was positively associated with a ‘persistent wheeze’ phenotype. Pet ownership was not associated with lung function at age 8 years, with the exception of positive associations of rodent and bird ownership with better lung function.ConclusionsCat ownership was associated with reduced risk, and rabbit and rodent ownership with increased risk, of wheezing during childhood. The mechanisms behind these differential effects warrant further investigation.

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“…It is also demonstrated that the IKZF3 -mutant mice would developed into the SLE-like phenotypes [10]. Besides SLE, several IKZF3 SNPs are also associated with rheumatoid arthritis (RA) [11], asthma [12-14] and primary biliary cirrhosis (PBC) [15], indicating its comprehensive involvement with autoimmune or immunological diseases. Up to now, few researches have investigated the relationship between IKZF3 polymorphisms and AITDs.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of IKZF3 Gene and Autoimmune Thyroid Diseases: Associated with Graves’ Disease but Not with Hashimoto’s Thyroiditis

Ding

Wang

et al. 2018

Cell Physiol Biochem

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Background/Aims: The IKZF3 gene encodes a zinc-finger protein that plays an important role in the proliferation and differentiation of B lymphocytes. Autoimmune thyroid diseases (AITDs), mainly include Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), are probably caused by the aberrant proliferation of B cells. The objective of this study was to explore the association between IKZF3 polymorphisms and AITDs. Methods: We examined 915 AITD patients (604 GD and 311 HT) and 814 healthy controls. IKZF3 variants (rs2941522, rs907091, rs1453559, rs12150079 and rs2872507) were tested by PCR-ligase detection reaction. Results: It was manifested that that the minor alleles of the five loci increased susceptibility to GD (p<0.05 for rs2941522, and p<0.01 for rs907091, rs1453559, rs12150079 and rs2872507) but in HT patients, these loci showed no significant difference compared with controls. Similarly, the genotype distributions of GD patients manifested obvious differences in all these loci compared with the control group, whereas no statistical differences were observed between HT patients and controls. Furthermore, bioinformatics tools were used to analyze rs1453559, rs12150079 and rs907091. These variants were believed to be the transcription regulator. Conclusion: It is the first time we reported the association between the IKZF3 polymorphisms and GD, indicating that IKZF3 gene tends to bean important risk factor for the development of GD.

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17q12-21 and asthma: interactions with early-life environmental exposures

Cited by 36 publications

References 40 publications

Trajectories of Lung Function during Childhood

Trajectories of Lung Function during Childhood

Associations of Pet Ownership with Wheezing and Lung Function in Childhood: Findings from a UK Birth Cohort

Polymorphisms of IKZF3 Gene and Autoimmune Thyroid Diseases: Associated with Graves’ Disease but Not with Hashimoto’s Thyroiditis

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