17β-Oestradiol may prolong reproduction in seasonally breeding freshwater gastropod molluscs

Benstead, Rachel; Baynes, Alice; Casey, Dáire; Routledge, Edwin J.; Jobling, Susan

doi:10.1016/j.aquatox.2010.11.005

Cited by 24 publications

(13 citation statements)

References 37 publications

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“…Because of the hormone-like action of estrogens and estrogen acting compounds and their ubiquity in environment, a number of efforts have been made to investigate their impacts on the ecosystems. To dates, there are numerous laboratory and field studies showing the adverse effects of natural estrogens and estrogenic EDCs in marine organisms that result in altered reproductive output in gastropods and altered sexual maturation in wild roach (Oehlmann et al, 2006;Benstead et al, 2011;Jobling et al, 2002;Jobling and Tyler, 2003;Lange A. et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Validation of Arxula Yeast Estrogen Screen assay for detection of estrogenic activity in water samples: Results of an international interlaboratory study

Hettwer¹,

Jähne²,

Frost³

et al. 2018

Science of The Total Environment

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Endocrine-active substances can adversely impact the aquatic ecosystems. A special emphasis is laid, among others, on the effects of estrogens and estrogen mimicking compounds. Effect-based screening methods like in vitro bioassays are suitable tools to detect and quantify endocrine activities of known and unknown mixtures. This study describes the validation of the Arxula-Yeast Estrogen Screen (A-YES®) assay, an effect-based method for the detection of the estrogenic potential of water and waste water. This reporter gene assay, provided in ready to use format, is based on the activation of the human estrogen receptor alpha. The user-friendly A-YES® enables inexperienced operators to rapidly become competent with the assay. Fourteen laboratories from four countries with different training levels analyzed 17β-estradiol equivalent concentrations (EEQ) in spiked and unspiked waste water effluent and surface water samples, in waste water influent and spiked salt water samples and in a mixture of three bisphenols. The limit of detection (LOD) for untreated samples was 1.8ng/L 17β-estradiol (E2). Relative repeatability and reproducibility standard deviation for samples with EEQ above the LOD (mean EEQ values between 6.3 and 20.4ng/L) ranged from 7.5 to 21.4% and 16.6 to 28.0%, respectively. Precision results are comparable to other frequently used analytical methods for estrogens. The A-YES® has been demonstrated to be an accurate, precise and robust bioassay. The results have been included in the ISO draft standard. The assay was shown to be applicable for testing of typical waste water influent, effluent and saline water. Other studies have shown that the assay can be used with enriched samples, which lower the LOD to the pg/L range. The validation of the A-YES® and the development of a corresponding international standard constitute a step further towards harmonized and reliable bioassays for the effect-based analysis of estrogens and estrogen-like compounds in water samples.

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Section: Introductionmentioning

confidence: 99%

Validation of Arxula Yeast Estrogen Screen assay for detection of estrogenic activity in water samples: Results of an international interlaboratory study

Hettwer¹,

Jähne²,

Frost³

et al. 2018

Science of The Total Environment

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“…Although all conditions were the same among the 3 regimes (EE2, fluoxetine, and the mixture), there may be seasonal differences in the performance of P. pomilia that are as yet to be described. Seasonal differences in reproduction have been observed in the gastropod Planorbarius corneus exposed to 17b-estradiol [46]. Moreover, seasonal differences in life history can impact the manifestation of toxicant-induced population level effects [47].…”

Section: Discussionmentioning

confidence: 99%

Effects of 17α‐ethynylestradiol, fluoxetine, and the mixture on life history traits and population growth rates in a freshwater gastropod

Luna

Plautz

Salice

2013

Enviro Toxic and Chemistry

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Pharmaceutical and personal care products (PPCPs), some of which have endocrine-disrupting effects at environmentally relevant concentrations, have been detected in many surface waters. The authors evaluated the effects of 2 common endocrine disrupting PPCPs on the life history traits of the snail, Physa pomilia, using a life table response experiment with snails raised in environmentally relevant concentrations of 17α-ethynylestradiol (EE2), fluoxetine, or their mixture. Exposure to fluoxetine or the mixture reduced snail reproduction, but EE2 did not. Generally, individual life history traits were affected minimally by the PPCPs, but when integrated using a demographic model, all 3 chemical exposure scenarios decreased population growth rates, with the EE2 and fluoxetine mixture causing the most adverse effects. Overall, the results provide additional insight into the effects of PPCPs on freshwater invertebrates and point to the importance of testing simultaneous exposures to multiple PPCPs. In addition, using a demographic model to integrate individual endpoints provided insights into effects that were not apparent from individual life history traits alone and suggest at least a potential for adverse ecological effects under realistic environmental exposures concentrations.

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“…However, development of intersex in bivalves, and effects on reproductive-and hatching rate in gastropods (Oehlmann et al 2000;Czech et al 2001;Jobling et al 2003;Segner et al 2003;Duft et al 2007;Langston et al 2007) suggest that molluscs may be receptive to EE2 and other estrogenic chemicals. The direction of effects on organism level endpoints may differ depending on life-history stage (Segner et al 2003), concentration of the EDC (Oehlmann et al 2000;Jobling et al 2003), and the duration and timing of exposure (Czech et al 2001;Schaefers et al 2007;Benstead et al 2011). Therefore, to evaluate the effect EDCs may have on a specific organism, critical life-history stages and the net effect on population growth rate need to be considered over a wide range of concentrations (Vanleeuwen et al 1985;Walthall and Stark 1997;Matthiessen 2008).…”

Section: Introductionmentioning

confidence: 97%

Effects of 17α-ethinylestradiol on individual life-history parameters and estimated population growth rates of the freshwater gastropods Radix balthica and Bithynia tentaculata

et al. 2011

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Studies of aquatic environments exposed to 17α-ethinylestradiol (EE2) have demonstrated detrimental effects on fish communities. However, much less is known about effects on macro-invertebrates and especially how long-term exposure may affect critical life stages and ultimately population dynamics. We studied the effects of EE2 on relevant endpoints for population growth in two common freshwater gastropods, Radix balthica and Bithynia tentaculata, that differ in reproductive, foraging and anti-predator strategies and endocrine systems. We quantified critical life-history parameters (mortality, somatic growth rate, days to and size at first reproduction, egg production and hatching success) in a concentration-response, life cycle experiment. The two species responded to EE2 exposure in different ways, B. tentaculata showing a significantly lower somatic growth rate and R. balthica a higher somatic growth rate. However, the magnitudes of the effects were small and EE2 exposure did not have any significant effect on estimated population growth rates for the two snail species. The significant effects of EE2 on individual endpoints, but not on population growth rate for both species, emphasise the importance of evaluating higher level effects from long-term exposure studies.

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17β-Oestradiol may prolong reproduction in seasonally breeding freshwater gastropod molluscs

Cited by 24 publications

References 37 publications

Validation of Arxula Yeast Estrogen Screen assay for detection of estrogenic activity in water samples: Results of an international interlaboratory study

Validation of Arxula Yeast Estrogen Screen assay for detection of estrogenic activity in water samples: Results of an international interlaboratory study

Effects of 17α‐ethynylestradiol, fluoxetine, and the mixture on life history traits and population growth rates in a freshwater gastropod

Effects of 17α-ethinylestradiol on individual life-history parameters and estimated population growth rates of the freshwater gastropods Radix balthica and Bithynia tentaculata

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