[18] Separation and quantification of carotenoids in human plasma

Khachik, Frederick; Beecher, Gary R.; Goli, Mudlagiri B.; Lusby, William R.; Daitch, Charles E.

doi:10.1016/0076-6879(92)13122-e

Cited by 60 publications

(36 citation statements)

References 24 publications

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“…Khachik et al have identified and quantified as many as 34 major and minor carotenoids including 8 metabolites in the extracts from human plasma and have proposed possible metabolic pathways leading to carotenoid metabolites [59,60]. The uneven distribution of carotenoids and xanthophylls among the various plasma lipoproteins, chylomicrons, VLDL, LDL, and HDL was then quantified.…”

Section: Plasma Carotenoid Binding Proteinsmentioning

confidence: 99%

Vertebrate and invertebrate carotenoid-binding proteins

Bhosale

Bernstein

2007

Archives of Biochemistry and Biophysics

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In invertebrates and vertebrates, carotenoids are ubiquitous colorants, antioxidants, and provitamin A compounds that must be absorbed from dietary sources and transported to target tissues where they are taken up and stabilized to perform their physiological functions. These processes occur in a specific and regulated manner mediated by high-affinity carotenoid-binding proteins. In this minireview, we examine the published literature on carotenoid-binding proteins in vertebrate and invertebrate systems, and we report our initial purification and characterization of a novel luteinbinding protein isolated from liver of Japanese quail (Coturnix japonica).

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Section: Plasma Carotenoid Binding Proteinsmentioning

confidence: 99%

Vertebrate and invertebrate carotenoid-binding proteins

Bhosale

Bernstein

2007

Archives of Biochemistry and Biophysics

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“…In ‘Western civilisation’ β-carotene is, in addition to lycopene (mainly in the USA), the carotenoid with the highest concentration in the human serum [23,24] and a intake of β-carotene results in higher all-trans retinoic acid (ATRA) concentrations [5,25,26]. (2) Lycopene is the red pigment of tomatoes and is present in the human nutrition in tomato-based products [17,18]. It is present in the human organism in the trans-form but also in the form of various geometric isomers [27,28].…”

Section: Introductionmentioning

confidence: 99%

“…Only about 60 carotenoids are important for human nutrition and also occur in the human organism [17,18]. …”

Section: Introductionmentioning

confidence: 99%

Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Rühl

2013

Int Arch Allergy Immunol

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Carotenoids are important derivatives of the human diet and occur in high concentrations in the human organism. Various carotenoids are also present in human breast milk and are transferred to breast-fed children. The alternative to breastfeeding is supplementation with an infant milk formula, but these formulas contain only a limited variety of carotenoids. Our question is: ‘What is the function of various carotenoids in human nutrition with a special emphasis on child development and the development of atopy?’ In this review, the mechanisms of action of the most important non-pro-vitamin A and pro-vitamin A carotenoids: α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin, lycopene and retinoids are discussed. In summary, the combination of carotenoids, especially lycopene, seems to be of great importance, and exclusive usage of β-carotene in infant formula may yield in an increased atopy prevalence mediated in various target organs like the skin, lungs and immune competent cells. We conclude that the determination of novel bioactive metabolites of various carotenoids, at various stages in different organs during atopy development, might be the key to understanding the potential importance of carotenoids on atopy development.

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“…The green fruits and vegetables are an excellent dietary source of lutein which is present at much higher concentrations than ß-carotene in these foods [4,5]. Detailed carotenoid analyses of extracts from plasma of human subjects consuming raw green fruits and vegetables have not detected carotenoid epoxides, whereas high concentrations of lutein, cx-carotene, and ß-carotene are normally present [6,7]. Lutein and its structural isomer, zeaxanthin, are also known to be the only two major carotenoids found in the macula of human retina [8].…”

Section: Qualitative and Quantitative Distribution Of Carotenoids In mentioning

confidence: 97%

“…The typical red fruits, tomatoes, pink grapefruit, and watermelon, are major dietary sources of carotenoids such as lycopene, t;-carotene, phytofluene, and phytoene, and to a lesser extent also contain neurosporene, y-carotene, and ß-carotene [5,12,13]. All of the hydrocarbon carotenoids of the yellowlred fruits and vegetables are absorbed by humans [6,7]. However, lycopene is one of the most important carotenoids in this group, since tomatoes and tomato-based food products, which are the main source of this compound, constitute a large proportion of Western diets [13].…”

Section: Qualitative and Quantitative Distribution Of Carotenoids In mentioning

confidence: 99%

Distribution of Carotenoids in Fruits and Vegetables as a Criterion for the Selection of Appropriate Chemopreventive Agents

Khachik

Nir²,

Ausich

et al. 1997

Food Factors for Cancer Prevention

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Summary. Common fruits and vegetables contain approximately 40 to 50 carotenoids. Carotenoid-containing fruits and vegetables can be classified into three groups: greens, yellowJred, and yellow/orange. The carotenoids present in greens comprise carotenoid epoxides, lutein, Ct.-carotene, and ß-carotene. The yellow/red group contains mostly hydrocarbon carotenoids such as lycopene, neurosporene, y-carotene, t;;-carotene, Ct.-carotene, ß-carotene, phytofluene, and phytoene. Yellow/orange fruits and vegetables, in addition to the carotenoids in the other two categories, contain a complex mixture of carotenoids including carotenol fatty acid esters. The effect of various methods of food preparation on qualitative and quantitative distribution of carotenoids in common fruits and vegetables is described. An approach to selection of a mixture of carotenoids as chemopreventive agents based on absorption and relative abundance of these compounds in human serum is discussed.

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[18] Separation and quantification of carotenoids in human plasma

Cited by 60 publications

References 24 publications

Vertebrate and invertebrate carotenoid-binding proteins

Vertebrate and invertebrate carotenoid-binding proteins

Non-Pro-Vitamin A and Pro-Vitamin A Carotenoids in Atopy Development

Distribution of Carotenoids in Fruits and Vegetables as a Criterion for the Selection of Appropriate Chemopreventive Agents

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