1845-P: Divergent Effects on T2D of Alleles Associated with Increased Liver Fat Reflect Differential Impact on Hepatic Glucose and Lipid Output: An IMI DIRECT Study
Abstract:Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) often coincide but the physiological relationship is unclear. Important clues are provided by human genetics: variants associated with NAFLD-risk have divergent effects on T2D. At TM6SF2 the NAFLD-risk allele (rs58542926:T) predisposes to T2D whilst at GCKR (rs1260326:T), it protects. We hypothesize that these divergent effects result from the impact of NAFLD-raising alleles on hepatic lipid output (HLO) and hepatic glucose output (HGO) respect… Show more
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