18F-FDG PET/CT for Detecting Sarcoma of the Aorta in a Patient with Takayasu Arteritis

Takahashi, Tomoko; Watanabe, Naoto; Wakasa, Minoru; Kajinami, Kouji; Tonami, Hisao

doi:10.1007/s13139-015-0347-z

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Although these parameters alongside other morphologic characteristics of the vasculature such as the vertebral artery tortuosity show promising results [147], they still represent patients at a In recent years, imaging modalities such as computed tomography (CT) combined with positron emission tomography (PET), using fluorodeoxyglucose (18F-FDG) or 18F-sodium fluoride (18F-NaF) administration provide geometrical, molecular, and functional information of aortic disease [56]. Several studies showed promising results regarding aortitis [80,81], aneurysm growth and future clinical events [103], atherosclerosis [179], and detecting malignant tumors of the aorta [199]. Photon Counting-CT is another promising technique, which is still in clinical trial, yet has proven its clinical value regarding improved spatial resolution, and optimized spectral imaging [221].…”

Section: Challenges In Clinical Managementmentioning

confidence: 99%

Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections

Ganizada,

Veltrop,

Akbulut

et al. 2024

Basic Res Cardiol

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Ascending thoracic aortic aneurysm (ATAA) remains a significant medical concern, with its asymptomatic nature posing diagnostic and monitoring challenges, thereby increasing the risk of aortic wall dissection and rupture. Current management of aortic repair relies on an aortic diameter threshold. However, this approach underestimates the complexity of aortic wall disease due to important knowledge gaps in understanding its underlying pathologic mechanisms.Since traditional risk factors cannot explain the initiation and progression of ATAA leading to dissection, local vascular factors such as extracellular matrix (ECM) and vascular smooth muscle cells (VSMCs) might harbor targets for early diagnosis and intervention. Derived from diverse embryonic lineages, VSMCs exhibit varied responses to genetic abnormalities that regulate their contractility. The transition of VSMCs into different phenotypes is an adaptive response to stress stimuli such as hemodynamic changes resulting from cardiovascular disease, aging, lifestyle, and genetic predisposition. Upon longer exposure to stress stimuli, VSMC phenotypic switching can instigate pathologic remodeling that contributes to the pathogenesis of ATAA.This review aims to illuminate the current understanding of cellular and molecular characteristics associated with ATAA and dissection, emphasizing the need for a more nuanced comprehension of the impaired ECM–VSMC network.

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Section: Challenges In Clinical Managementmentioning

confidence: 99%

Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections

Ganizada,

Veltrop,

Akbulut

et al. 2024

Basic Res Cardiol

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“…3 ). 96 97 98 In patients with peripheral or splanchnic emboli, an aortic sarcoma should be included in differential diagnosis; therefore, a whole-body PET/CT scan can be used for comprehensive staging. 99 In one study of primary sarcomas of the aorta and arteries, 100 FDG PET/CT showed high metabolic activity in sarcomas, local embolic spread in the pulmonary vasculature of the lungs, distant metastases to the brain, and high metabolic activity at the site of vascular filling defects, which strengthens the suspicion of malignant disease.…”

Section: Aortic Tumormentioning

confidence: 99%

Role of PET/CT in the Evaluation of Aortic Disease

Kim

Song

2018

Chonnam Med J

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Positron emission tomography (PET) /computed tomography (CT) has been established as a standard imaging modality in the evaluation of malignancy. Although PET/CT has played a major role in the management of oncology patients, its clinical use has also increased for various disorders other than malignancy. Growing evidence shows that PET/CT images have many advantages in aortic disease as well. This review article addresses the potential role of PET/CT in diseases involving the aorta, emphasizing its usefulness with regard to acute thoracic aortic syndromes, aortic aneurysm, atherosclerotic lesions, aortitis and aortic tumors.

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