2010
DOI: 10.1007/s13139-010-0036-x
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18F-FDG PET/CT is Useful for Pretreatment Assessment of the Histopathologic Type of Thymic Epithelial Tumors

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Cited by 22 publications
(34 citation statements)
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“…Briefly, expression of the ALK protein could be a contributing factor to enhanced glycolysis as it activates the oncogenic signalings such as Ras-ERK, PI3K-Akt pathways and the consecutive mTOR/HIF-1α pathway. 18 F-FDG-avidity or increases in SUV reflect in parallel the likelihood for an aggressive disease or a poor prognosis for malignant tumors including lymphoma [11,[23][24][25][26]. Interestingly, however, ALK-positive ALCL which is known to have a better prognosis and clinical outcome than ALK-negative ALCL, showed more 18 F-FDG-avidity on baseline PET.…”
Section: Discussionmentioning
confidence: 99%
“…Briefly, expression of the ALK protein could be a contributing factor to enhanced glycolysis as it activates the oncogenic signalings such as Ras-ERK, PI3K-Akt pathways and the consecutive mTOR/HIF-1α pathway. 18 F-FDG-avidity or increases in SUV reflect in parallel the likelihood for an aggressive disease or a poor prognosis for malignant tumors including lymphoma [11,[23][24][25][26]. Interestingly, however, ALK-positive ALCL which is known to have a better prognosis and clinical outcome than ALK-negative ALCL, showed more 18 F-FDG-avidity on baseline PET.…”
Section: Discussionmentioning
confidence: 99%
“…On 18F-FDG PET-CT they usually present as large multilobulated masses with areas of necrosis and calcification and increased 18F-FDG uptake. SUVmax can be used to differentiate thymic carcinoma from thymoma, with the former usually having a SUVmax of $7 or more (22,28). In addition, presence of mediastinal lymphadenopathy and distant metastasis on 18F-FDG PET-CT suggest thymic carcinoma (Fig.…”
Section: Thymic Carcinomamentioning
confidence: 99%
“…18 F-FDG PET/CT demonstrated enhanced glucose metabolism in the peripheral portion of the mass with a central metabolic defect. However, 18 F-FDG PET/CT can show a hypermetabolic mediastinal mass-like lesion in other malignancies such as thymic carcinoma, lymphoma, and some benign lesions such as sarcoidosis; thus, it may be challenging to discriminate MFH from other mediastinal neoplasms by the pattern of 18 F-FDG uptake [12][13][14]. According to several reports of MFH developing in the kidney, maxillary sinus, brain and the lung, all MFHs showed high 18 F-FDG uptake with a central metabolic defect, which was similar with the present case [6][7][8][9].…”
Section: Discussionmentioning
confidence: 99%