18F-FDG Retention Index and Biologic Prognostic Parameters in Breast Cancer

Vicente, Ana María García; Castrejón, Á. Soriano; Calatayud, Fernanda Relea; Muñoz, A. Palomar; Martín, A. León; López-Muñíz, Ignacio Chacón; Sánchez, María del Carmen; García, J.M. Cordero; Nakayo, E. Mitsuro Becerra

doi:10.1097/rlu.0b013e31823926c9

Cited by 30 publications

(17 citation statements)

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“…Previous studies showed an association between SUVmax1, SUVmax2, RI, and biological and clinical prognostic parameters in patients with breast cancer. [ 19 20 ] In contrast with the previous reports, our results suggested an association between biological and clinical prognostic parameters in breast cancer and SUVmean1, SUVmean2, and RImean. Due to its ability to provide whole body imaging in a single session, PET-CT has been successfully used to assess the extent of the disease in patients with breast cancer in recent years.…”

Section: Discussioncontrasting

confidence: 99%

“…In a study carried out by García Vicente et al ., who investigated the association between biological prognostic factors and early SUVmax, SUVmax2, and RI, a significant association was found between RI and ER and PR. [ 20 ] Besides, in another study carried out by García Vicente et al ., who investigated RI and biological prognostic parameters, no significant associations with estrogen and progesterone were observed as compared to a significant association between RI and C-erbB2. [ 20 ] In the study carried out by Kumar et al ., ER, PR, and C-erbB2 had a significant correlation with the SUVmax of the primary lesion.…”

Section: Discussionmentioning

confidence: 99%

“…[ 20 ] Besides, in another study carried out by García Vicente et al ., who investigated RI and biological prognostic parameters, no significant associations with estrogen and progesterone were observed as compared to a significant association between RI and C-erbB2. [ 20 ] In the study carried out by Kumar et al ., ER, PR, and C-erbB2 had a significant correlation with the SUVmax of the primary lesion. [ 21 ] Mavi et al .…”

Section: Discussionmentioning

confidence: 99%

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Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value?

et al. 2017

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It was aimed to investigate the correlation between maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and retention index (RI), which represents the quantitative evaluation of the uptake of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) used in positron emission tomography (PET) and clinicopathologic as well as biologic prognostic factors. Forty-one women with breast cancer who were histopathologically diagnosed were included in this study. Neoadjuvant chemotherapy was applied to all patients before PET/computed tomography (CT). After FDG injection, PET/CT screening was applied within the 1st h (PET-1) and in the 2nd h (PET-2). SUVmax, SUVmean, SUVmax RI, and SUVmean RI of every image were calculated qualitatively and semiquantitatively. The correlation between quantitative and semiquantitative PET parameters and biologic as well as clinicopathologic prognosis factors was evaluated. Statistically, significant positive correlation was found between lymph nodes (LNs), which were evaluated by clinical picture, clinical stage as well as histopathologically and quantitative PET parameters (SUVmax1, SUVmax2,, RImax, SUVmean1, SUVmean2, RImean) (P < 0.05). While statistically significant correlation with RImax was detected only by LN (histopathological), correlations with RImean were detected by clinical picture, clinical stage, metabolic stage, and LN (histopathological). Statistically, significant correlation was found between RImax and estrogen receptor in patients who were histopathologically diagnosed with invasive ductal carcinoma (n = 34) (P < 0.05). We detected correlations between biologic and clinicopathologic prognostic factors and SUVmax as well as SUVmean values in breast carcinoma. SUVmean values may provide important knowledge when the correlation between prognostic factors and PET parameters is investigated even if they are not used routinely.

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Section: Discussionmentioning

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Section: Discussionmentioning

confidence: 99%

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Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value?

et al. 2017

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“…However, in light of the ability to evaluate prognosis using imaging parameters in a preoperative assessment, our results will have clinical implications. Our current findings are consistent with previously reported results from Garcia et al, [ 21 ] who suggested that the 18 F-FDG retention index showed prognostic value, and Choi et al, [ 22 ] who demonstrated that both SUV max at a single time point and ADC values could be useful for predicting IDC prognosis. However, these prior studies did not include DTP PET parameters for survival analysis.…”

Section: Discussionsupporting

confidence: 93%

Percentage change of primary tumor on 18F-FDG PET/CT as a prognostic factor for invasive ductal breast cancer with axillary lymph node metastasis

et al. 2017

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We evaluated the prognostic value of quantitative parameters using dual time point (DTP) 18F-FDG PET/CT (PET/CT) in invasive ductal breast cancer (IDC) with metastatic axillary lymph nodes (ALN) as compared with dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) MRI.Seventy patients with IDC and metastatic ALN were retrospectively registered. Static PET parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG) of primary tumor, SUVmax of ALN (SUVALN), and percentage changes (Δ%) in those parameters were measured with DTP PET/CT. From DCE MRI, peak enhancement value, total tumor angio volume, and proportions of kinetic curve types on delayed-phases were investigated. The average apparent diffusion coefficient (ADCavg) was estimated on DWI. To demonstrate the prognostic value of quantitative imaging parameters for recurrence-free survival (RFS), univariate and multivariate analyses were performed using those parameters and clinicohistologic variables.All static PET parameters, %ΔSUVmax, %ΔMTV, and %ΔSUVALN on DTP PET/CT and ADCavg on DWI were significantly predictive for disease recurrence. Of clinicohistologic variables, pathologic tumor (pT) diameter, pathologic ALN stage, tumor grade, and hormonal status also were significantly prognostic. After multivariate analysis, %ΔSUVmax > 25.05 (P = .043), ADCavg ≤ 1016.55 (P = .020), pT diameter > 3 cm (P = .001), and ER negative status (P = .002) were independent prognostic factors for poor outcome.Only %ΔSUVmax of the primary tumor on PET/CT together with ADCavg, pT diameter, and ER status was an independent prognostic factor for predicting relapse in IDC with metastatic ALN. Percentage change of primary tumor on preoperative PET/CT may be a valuable imaging marker for selecting IDC patients that require adjunct treatment to prevent relapse.

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“…In the last few years the field of oncology developed renewed interest in cancer cell metabolism reviving Otto Warburg's findings that cancer cells prefer aerobic glycolysis. In fact the increased glucose uptake of cancer cells facilitated the development of develop 18F-FD glucose PET as a standard diagnostic tool in various solid tumors 40,41 , enlisting altered metabolism as a new hallmark of cancer 42 .…”

Section: 0 Mechanistic Insights Into the Cellular Function Of Rab25mentioning

confidence: 99%

Rab25 in cancer: a brief update

Mitra

Cheng

Mills

2012

Biochemical Society Transactions

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Derailed endocytosis is a hallmark of cancer. The endocytic pathway, as demonstrated by our laboratory, is a frequent target of genomic aberrations in cancer and plays a critical role in the maintenance of cellular polarity, stem cell function, bioenergetics, proliferation, motility, invasion, metastasis, apoptosis and autophagy. The Rab GTPases, along with their effectors, are critical regulators of this endocytic machinery and can have a huge impact on the cellular itinerary of growth and metabolism. Rab25 is an epithelial-cell-specific member of the Rab GTPase superfamily, sharing close homology with Rab11a, the endosomal recycling Rab GTPase. RAB25 has been implicated in various cancers, with reports presenting it as both an oncogene and a tumour-suppressor gene. At the cellular level, Rab25 was shown to contribute to invasiveness of cancer cells by regulating integrin trafficking. Recently, our laboratory uncovered a critical role for Rab25 in cellular energetics. Assimilating all of the existing evidence, in the present review, we give an updated overview of the complex and often context-dependent role of Rab25 in cancer.

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18F-FDG Retention Index and Biologic Prognostic Parameters in Breast Cancer

Abstract: The retention index showed the best relation with biologic and clinical parameters compared with isolated SUVmax values for what could be a predictive marker of tumor biologic behavior.

Cited by 30 publications

References 19 publications

Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value?

Considering the relationship between quantitative parameters and prognostic factors in breast cancer: Can mean standardized uptake value be an alternative to maximum standardized uptake value?

Percentage change of primary tumor on 18F-FDG PET/CT as a prognostic factor for invasive ductal breast cancer with axillary lymph node metastasis

Rab25 in cancer: a brief update

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