18S rRNA gene sequence-structure phylogeny of the Trypanosomatida (Kinetoplastea, Euglenozoa) with special reference to Trypanosoma

Borges, Alyssa; Engstler, Markus; Wolf, Matthias

doi:10.1016/j.ejop.2021.125824

Cited by 12 publications

(18 citation statements)

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“…Trypanosoma is a monophyletic genus that can be divided into 17 subgenera of two lineages: aquatic and terrestrial ( Kostygov et al, 2021 ). The human parasites T. brucei and T. cruzi are both of terrestrial lineage and have independent evolutionary stories ( Hamilton and Stevens, 2017 ; Borges et al, 2021 ; Kostygov et al, 2021 ). This independence can be observed to a certain extent in their specific repertoires of surface molecules, which are related to their distinct lifestyles, survival strategies, and interactions with their hosts.…”

Section: Evolution and Cell Surface Composition Of Trypanosomamentioning

confidence: 99%

“…Closely related to T. brucei , other African trypanosomes are of socio-economic importance, such as Trypanosoma congolense , Trypanosoma vivax , Trypanosoma evansi , and Trypanosoma equiperdum ( Hoare, 1972 ; Stevens and Gibson, 1999 ; Borges et al, 2021 ; Kostygov et al, 2021 ). Due to phylogenetic similarities, T. evansi and T. equiperdum were suggested to be subspecies of T. brucei ( Lai et al, 2008 ; Carnes et al, 2015 ; Kamidi et al, 2017 ; Borges et al, 2021 ). However, such a taxonomical change is not allowed by the International Code of Zoological Nomenclature ( ICZN, 1999 ; Molinari and Moreno, 2018 ).…”

Section: Evolution and Cell Surface Composition Of Trypanosomamentioning

confidence: 99%

“…The other important human pathogen, T. cruzi , is closely related to other parasites of mammals, such as Trypanosoma rangeli and Trypanosoma conorhini ( Hoare, 1972 ; Stevens and Gibson, 1999 ; Borges et al, 2021 ; Kostygov et al, 2021 ). Genomic analyses of T. rangeli and T. conorhini strains revealed a similar number of GPI-anchored proteins and the presence of multigene families.…”

Section: Evolution and Cell Surface Composition Of Trypanosomamentioning

confidence: 99%

“…Due to the extracellular lifestyle of T. carassii ( Dóró et al, 2019 ), it is possible to suggest that the mucin-like coat of T. carassii acts only in parasite protection. Although still under debate, it is likely that the aquatic lineage has diverged later in the evolution of Trypanosoma as a split from a terrestrial species ( Hamilton and Stevens, 2017 ; Borges et al, 2021 ). The presence of mucin-like proteins in T. carassii could be explained by this hypothesis, but this can only be confirmed by ancestral character reconstruction.…”

Section: Evolution and Cell Surface Composition Of Trypanosomamentioning

confidence: 99%

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The Glycosylphosphatidylinositol Anchor: A Linchpin for Cell Surface Versatility of Trypanosomatids

Borges

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Engstler

et al. 2021

Front. Cell Dev. Biol.

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The use of glycosylphosphatidylinositol (GPI) to anchor proteins to the cell surface is widespread among eukaryotes. The GPI-anchor is covalently attached to the C-terminus of a protein and mediates the protein’s attachment to the outer leaflet of the lipid bilayer. GPI-anchored proteins have a wide range of functions, including acting as receptors, transporters, and adhesion molecules. In unicellular eukaryotic parasites, abundantly expressed GPI-anchored proteins are major virulence factors, which support infection and survival within distinct host environments. While, for example, the variant surface glycoprotein (VSG) is the major component of the cell surface of the bloodstream form of African trypanosomes, procyclin is the most abundant protein of the procyclic form which is found in the invertebrate host, the tsetse fly vector. Trypanosoma cruzi, on the other hand, expresses a variety of GPI-anchored molecules on their cell surface, such as mucins, that interact with their hosts. The latter is also true for Leishmania, which use GPI anchors to display, amongst others, lipophosphoglycans on their surface. Clearly, GPI-anchoring is a common feature in trypanosomatids and the fact that it has been maintained throughout eukaryote evolution indicates its adaptive value. Here, we explore and discuss GPI anchors as universal evolutionary building blocks that support the great variety of surface molecules of trypanosomatids.

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Section: Evolution and Cell Surface Composition Of Trypanosomamentioning

confidence: 99%

Section: Evolution and Cell Surface Composition Of Trypanosomamentioning

confidence: 99%

Section: Evolution and Cell Surface Composition Of Trypanosomamentioning

confidence: 99%

Section: Evolution and Cell Surface Composition Of Trypanosomamentioning

confidence: 99%

See 2 more Smart Citations

The Glycosylphosphatidylinositol Anchor: A Linchpin for Cell Surface Versatility of Trypanosomatids

Borges

Link

Engstler

et al. 2021

Front. Cell Dev. Biol.

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“…Trypanosomes (Kinetoplastida, Trypanosomatidae, Trypanosoma) are vector-borne protozoan parasites that infect vertebrates [1][2][3]. Several trypanosome species are important human health concerns as the etiological agents of American trypanosomiasis (Chagas disease), Trypanosoma cruzi [4] and human African trypanosomiasis (sleeping sickness), T. brucei rhodesiense and T. brucei gambiense [5].…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic evidence for a clade of tick-associated trypanosomes

et al. 2023

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Background Trypanosomes are protozoan parasites of vertebrates that are of medical and veterinary concern. A variety of blood-feeding invertebrates have been identified as vectors, but the role of ticks in trypanosome transmission remains unclear. Methods In this study, we undertook extensive molecular screening for the presence and genetic diversity of trypanosomes in field ticks. Results Examination of 1089 specimens belonging to 28 tick species from Europe and South America led to the identification of two new trypanosome strains. The prevalence may be as high as 4% in tick species such as the castor bean tick Ixodes ricinus, but we found no evidence of transovarial transmission. Further phylogenetic analyses based on 18S rRNA, EF1-α, hsp60 and hsp85 gene sequences revealed that different tick species, originating from different continents, often harbour phylogenetically related trypanosome strains and species. Most tick-associated trypanosomes cluster in a monophyletic clade, the Trypanosoma pestanai clade, distinct from clades of trypanosomes associated with transmission by other blood-feeding invertebrates. Conclusions These observations suggest that ticks may be specific arthropod hosts for trypanosomes of the T. pestanai clade. Phylogenetic analyses provide further evidence that ticks may transmit these trypanosomes to a diversity of mammal species (including placental and marsupial species) on most continents. Graphical Abstract

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Assessment of genetic diversity of Trypanosoma evansi in the domestic animal populations through ITS-1 gene sequence analysis

Verma,

Punia,

Das

et al. 2023

Parasitol Res

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18S rRNA gene sequence-structure phylogeny of the Trypanosomatida (Kinetoplastea, Euglenozoa) with special reference to Trypanosoma

Cited by 12 publications

References 69 publications

The Glycosylphosphatidylinositol Anchor: A Linchpin for Cell Surface Versatility of Trypanosomatids

The Glycosylphosphatidylinositol Anchor: A Linchpin for Cell Surface Versatility of Trypanosomatids

Phylogenetic evidence for a clade of tick-associated trypanosomes

Assessment of genetic diversity of Trypanosoma evansi in the domestic animal populations through ITS-1 gene sequence analysis

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