19F magnetic resonance imaging

Holland, G. N.; Bottomley, Paul A.; Hinshaw, W. S.

doi:10.1016/0022-2364(77)90263-3

Cited by 150 publications

(130 citation statements)

References 12 publications

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“…The naturally occurring stable fluorine isotope 19 F (100%) is MR active and exhibits a sensitivity close to the 1 H nucleus. 10,11 Because of the lack of any 19 F background in the body, observed signals originating from injected 19 F-containing compounds exhibit an excellent degree of specificity. The merging of recorded 19 F images with simultaneously acquired, morphologically matching 1 H images enables an exact anatomic localization of fluorinated substances as "hot spots."…”

Section: Editorial P 109 Clinical Perspective P 148mentioning

confidence: 99%

In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging

Flögel

Ding²,

Hardung³

et al. 2008

Circulation

318

430

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Background— In this study, we developed and validated a new approach for in vivo visualization of inflammatory processes by magnetic resonance imaging using biochemically inert nanoemulsions of perfluorocarbons (PFCs). Methods and Results— Local inflammation was provoked in 2 separate murine models of acute cardiac and cerebral ischemia, followed by intravenous injection of PFCs. Simultaneous acquisition of morphologically matching proton ( 1 H) and fluorine ( 19 F) images enabled an exact anatomic localization of PFCs after application. Repetitive 1 H/ 19 F magnetic resonance imaging at 9.4 T revealed a time-dependent infiltration of injected PFCs into the border zone of infarcted areas in both injury models, and histology demonstrated a colocalization of PFCs with cells of the monocyte/macrophage system. We regularly found the accumulation of PFCs in lymph nodes. Using rhodamine-labeled PFCs, we identified circulating monocytes/macrophages as the main cell fraction taking up injected nanoparticles. Conclusions— PFCs can serve as a “positive” contrast agent for the detection of inflammation by magnetic resonance imaging, permitting a spatial resolution close to the anatomic 1 H image and an excellent degree of specificity resulting from the lack of any 19 F background. Because PFCs are nontoxic, this approach may have a broad application in the imaging and diagnosis of numerous inflammatory disease states.

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Section: Editorial P 109 Clinical Perspective P 148mentioning

confidence: 99%

In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging

Flögel

Ding²,

Hardung³

et al. 2008

Circulation

318

430

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“…ϫ f␥ e 2 B 1e 2 T 1e T 2e /(1 ϩ ␥ e 2 B 1e 2 T 1e T 2e )) [4] where T 1e and T 2e are the electron spin relaxation times and B 1e is the EPR irradiation field. T EPR is the EPR irradiation time and E inf is the enhancement factor at infinite EPR irradiation field and infinite concentration of the paramagnetic contrast agent.…”

Section: Theorymentioning

confidence: 99%

“…The feasibility of 19 F imaging was first demonstrated nearly 25 years ago (4). Since then, 19 F imaging has been used to study biological processes including metabolism (5), tumor growth (6,7), cerebral blood flow (8), drug distribution (9 -11), enzyme activities (12), blood oxygenation (13)(14)(15), perfusion (16), etc.…”

mentioning

confidence: 99%

Fluorine electron double resonance imaging for ¹⁹F MRI in low magnetic fields

Murugesan

English

Reijnders

et al. 2002

Magnetic Resonance in Med

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“…In the 1970s, the first example of 19 F MRI, which involved images of NaF and perfluoro compounds, was reported. 15) Since then, a significant number of 19 F MRI studies have been reported. 16,17) These studies are mainly categorized into two groups: (1) studies to localize fluorinated compounds such as 5-fluorouracil (5-FU), which is a chemotherapeutic agent 18) or (2) studies of biologically important molecules using 19 F MRI probes to change the MRI properties according to the concentration of the target biomolecules or environmental changes.…”

mentioning

confidence: 99%

Development of Molecular Imaging Tools to Investigate Protein Functions by Chemical Probe Design

Mizukami

2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Molecular imaging technologies, which enable the visualization of the behaviors or functions of biomolecules in living systems, have received considerable attention from life scientists. Novel imaging technologies that overcome the limitations of current imaging techniques are desired. In this review, two independent technologies that were recently developed by the authors are described. The first technology is for smart 19 F magnetic resonance imaging (MRI) probes that were developed for in vivo applications. These probes were developed by exploiting paramagnetic relaxation enhancement in order to detect hydrolase activity. With respect to cellular applications, gene expression in cells was visualized using one of the 19 F MRI probes. It was confirmed that this probe design principle is effective for various hydrolases, and broad applications are expected. The second technology is for practical protein labeling. This labeling method is based on a mutant b b -lactamase and its specific labeling probes. Since the probe is fluorescence resonance energy transfer (FRET)-based, this labeling method achieves both specific and fluorogenic labeling of target proteins. In addition, derivatization of the probe enabled the labeling of intracellular proteins and the modification of various functional molecules.

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19F magnetic resonance imaging

Cited by 150 publications

References 12 publications

In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging

In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging

Fluorine electron double resonance imaging for ¹⁹F MRI in low magnetic fields

Development of Molecular Imaging Tools to Investigate Protein Functions by Chemical Probe Design

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19F magnetic resonance imaging

Cited by 150 publications

References 12 publications

In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging

In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging

Fluorine electron double resonance imaging for 19F MRI in low magnetic fields

Development of Molecular Imaging Tools to Investigate Protein Functions by Chemical Probe Design

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Fluorine electron double resonance imaging for ¹⁹F MRI in low magnetic fields