1H Detected 13C Echo Planar Imaging

Hudson, Alex M. J.; Köckenberger, Walter; Heidenreich, Michael; Chandrakumar, N.; Kimmich, Rainer; Bowtell, Richard

doi:10.1006/jmre.2002.2516

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…Images are run as a function of time after dipping the cotyledons in the nutrient bath. The spin echo images-in combination with EPI based experiments (Hudson et al 2002) that were about six times faster-clearly demonstrate the selective unloading of sucrose in the cortex parenchyma of the hypocotyl region, as opposed to the pith.…”

Section: I Iii Imentioning

confidence: 80%

Coherence Transfer in Spatially Resolved NMR

Chandrakumar

2008

Magn Reson�Insights

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Abstract:We present an overview of some applications of coherence transfer experiments in spatially resolved NMR, with examples from imaging and volume localized spectroscopy. While the major preoccupation of spatially resolved NMR experiments is normally with the dominant component (e.g. water) of heterogeneous multi-component systems, the interest in minor components (e.g. metabolites) of such systems is a strong motivation to develop and apply special techniques. Unlike water, these components typically involve scalar coupled spin systems. They lend themselves therefore to investigations based on the correlated evolution of coupled spins. Specifi cally, we briefl y describe in this contribution the spatially resolved version of multiple quantum experiments, indirect detection experiments and spin correlation experiments.

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Section: I Iii Imentioning

confidence: 80%

Coherence Transfer in Spatially Resolved NMR

Chandrakumar

2008

Magn Reson�Insights

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“…(17.32) is then [38] C (x, t) = 1 2 C 0 erfc x 2 √ Dt (17.34) in perfect agreement with the experimental data shown in Figure 17.10. Figure 17.11 shows a typical CYCLCROP pulse sequence [39][40][41][42] for onedimensional mapping of 13 C concentrations along the z direction. .…”

Section: Nmr Microscopy Diffusometry Techniquesmentioning

confidence: 99%

Anomalous Molecular Displacement Laws in Porous Media and Polymers Probed by Nuclear Magnetic Resonance Techniques

Kimmich

Fatkullin

Kehr

et al. 2008

Anomalous Transport

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“…Fast imaging schemes can be employed to improve MRSI sensitivity. For example, echo-planar MRSI methods using fast k-space mapping reduce scanning time without sacrificing signal-to-noise ratios [151][152][153][154]. The SENSE [155] technique of parallel imaging has been used to improve the spatial resolution of MRSI, taking advantage of multi-coil configurations on the clinical scanners to reduce the field of view (FOV) and scanning time.…”

Section: Future Perspectives-ultra-fast 3d Mrsi Of Cancermentioning

confidence: 99%

Magnetic Resonance Spectroscopic Imaging of Tumor Metabolic Markers for Cancer Diagnosis, Metabolic Phenotyping, and Characterization of Tumor Microenvironment

Xu²,

Shkarin³

et al. 2004

Disease Markers

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Cancer cells display heterogeneous genetic characteristics, depending on the tumor dynamic microenvironment. Abnormal tumor vasculature and poor tissue oxygenation generate a fraction of hypoxic tumor cells that have selective advantages in metastasis and invasion and often resist chemo- and radiation therapies. The genetic alterations acquired by tumors modify their biochemical pathways, which results in abnormal tumor metabolism. An elevation in glycolysis known as the “Warburg effect” and changes in lipid synthesis and oxidation occur. Magnetic resonance spectroscopy (MRS) has been used to study tumor metabolism in preclinical animal models and in clinical research on human breast, brain, and prostate cancers. This technique can identify specific genetic and metabolic changes that occur in malignant tumors. Therefore, the metabolic markers, detectable by MRS, not only provide information on biochemical changes but also define different metabolic tumor phenotypes. When combined with the contrast-enhanced Magnetic Resonance Imaging (MRI), which has a high sensitivity for cancer diagnosis, in vivo magnetic resonance spectroscopic imaging (MRSI) improves the diagnostic specificity of malignant human cancers and is becoming an important clinical tool for cancer management and care. This article reviews the MRSI techniques as molecular imaging methods to detect and quantify metabolic changes in various tumor tissue types, especially in extracranial tumor tissues that contain high concentrations of fat. MRI/MRSI methods have been used to characterize tumor microenvironments in terms of blood volume and vessel permeability. Measurements of tissue oxygenation and glycolytic rates by MRS also are described to illustrate the capability of the MR technology in probing molecular information non-invasively in tumor tissues and its important potential for studying molecular mechanisms of human cancers in physiological conditions.

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1H Detected 13C Echo Planar Imaging

Cited by 8 publications

References 17 publications

Coherence Transfer in Spatially Resolved NMR

Coherence Transfer in Spatially Resolved NMR

Anomalous Molecular Displacement Laws in Porous Media and Polymers Probed by Nuclear Magnetic Resonance Techniques

Magnetic Resonance Spectroscopic Imaging of Tumor Metabolic Markers for Cancer Diagnosis, Metabolic Phenotyping, and Characterization of Tumor Microenvironment

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