1H NMR-based metabolomic analysis of nine organophosphate flame retardants metabolic disturbance in Hep G2 cell line

Gu, Jinping; Su, Feng; Hong, Pan-Pan; Zhang, Quan; Zhao, Meirong

doi:10.1016/j.scitotenv.2019.02.055

Cited by 37 publications

(24 citation statements)

References 61 publications

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“…In contrast, phosphate conjugation dominates phase II metabolism of tributyl phosphates (TBPs) in earthworms additionally (Wang et al, 2018a(Wang et al, , 2018b. The metabolism of OPFRs in earthworm corresponds with HepG cell in vitro metabolic experiment, in which two modules (glutathione biosynthesis and histidine degradation) and three metabolic pathways (alanine, aspartate, and glutamine metabolism; glycine, serine, and threonine metabolism; and glutamine and glutamate metabolism) were dominant (Jokanović, 2001;Gu et al, 2019). OPFRs transformed by soil animal may be detoxified to some extent, which prompts soil back to its initial condition (González-Alcaraz et al, 2020).…”

Section: Biotic Transformationsmentioning

confidence: 99%

Environmental fate and effects of organophosphate flame retardants in the soil-plant system

et al. 2021

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Organophosphate flame retardants (OPFRs), as a replacement for polybrominated diphenyl ethers (PBDEs), are of increasing concern due to their high production over the years. Soil is the major environmental reservoir and interchange for OPFRs. OPFRs in soil could be transferred to the food chain, and pose potential ecological and human health risks. This review focused on the environmental fate and effects of typical OPFRs in the soil-plant system. We concluded that the sorption and transformation behaviors of OPFRs due to their crucial impact on bioavailability. The root uptake and translocation of OPFRs by plants were summarized with analyses of their potential affecting factors. The in planta transformation and potential ecological effects of OPFRs were also briefly discussed. Finally, we highlighted several research gaps and provided suggestions for future research, including the development of simulative/computative methods to evaluate the bioavailability of OPFRs, the effects of root exudates and rhizosphere microorganisms on the bioavailability and plant uptake of OPFRs, and the development of green and sustainable technologies for in situ remediation of OPFRs-contaminated soil.

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Section: Biotic Transformationsmentioning

confidence: 99%

Environmental fate and effects of organophosphate flame retardants in the soil-plant system

et al. 2021

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“…However, some studies have also reported that the chronic neurotoxic mechanism of organophosphates cannot be related only to cholinesterase inhibition. Therefore, the molecular mechanism behind their toxicity is still elusive [158].…”

Section: Environmental Impacts Of Opfrsmentioning

confidence: 99%

A Review of a Class of Emerging Contaminants: The Classification, Distribution, Intensity of Consumption, Synthesis Routes, Environmental Effects and Expectation of Pollution Abatement to Organophosphate Flame Retardants (OPFRs)

Yang

Zhao

et al. 2019

IJMS

184

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Organophosphate flame retardants (OPFRs) have been detected in various environmental matrices and have been identified as emerging contaminants (EC). Given the adverse influence of OPFRs, many researchers have focused on the absorption, bioaccumulation, metabolism, and internal exposure processes of OPFRs in animals and humans. This paper first reviews the evolution of various types of flame retardants (FRs) and the environmental pollution of OPFRs, the different absorption pathways of OPFRs by animals and humans (such as inhalation, ingestion, skin absorption and absorption), and then summarizes the environmental impacts of OPFRs, including their biological toxicity, bioaccumulation, persistence, migration, endocrine disruption and carcinogenicity. Based on limited available data and results, this study also summarizes the bioaccumulation and biomagnification potential of OPFRs in different types of biological and food nets. In addition, a new governance idea for the replacement of existing OPFRs from the source is proposed, seeking environmentally friendly alternatives to OPFRs in order to provide new ideas and theoretical guidance for the removal of OPFRs.

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“…to be transferred to offspring, resulting in developmental neurotoxicity (Du et al, 2015;Liu et al, 2013;Yu et al, 2017;Zhang et al, 2018a;Zhang et al, 2018b). Additional adverse effects of OPE exposure include developmental toxicity (Dasgupta et al, 2018;Dasgupta et al, 2017;Jacobsen et al, 2017;Li et al, 2018;Oliveri et al, 2018;Yan & Hales, 2018), oxidative stress (Chen et al, 2015a;Chen et al, 2015b;Gu et al, 2019;Yan et al, 2017), thyroid disruption (Fernie et al, 2017;Hill et al, 2018;Liu et al, 2019;Preston et al, 2017), neurotoxicity (Andresen et al, 2004;Hong et al, 2018;Shi et al, 2018;Slotkin et al, 2017), carcinogenicity (Hoffman et al, 2017b;Ni et al, 2007;Van den Eede et al, 2013b), endocrine disruption (Arukwe et al, 2016;Kojima et al, 2013;Kojima et al, 2016;, and cellular toxicity (Shen et al, 2019;Canbaz et al, 2017;Crump et al, 2012;Shen et al, 2019;Su et al, 2014a agonists, similar to their parent compound TBOEP as well as TEHP, and TNBP (Kojima et al, 2016). Metabolism can significantly influence the accumulation and adverse effects of chemicals in organisms, however the transformation of OPEs and distribution of their metabolites are still unknown.…”

Section: Metabolismmentioning

confidence: 99%

Metabolism and fate of organophosphate ester (OPE) contaminants in rainbow trout (Oncorhynchus mykiss) using in vitro lab-based studies

Large¹

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Due to ubiquitous use of organophosphate esters (OPEs) as flame retardants and plasticizers, they have been found at high concentrations in a variety of environmental media while having low or non-detectable levels in biota, including fish. The exposure and fate of OPEs in fish depends on understanding the toxicokinetics, though studies on OPE metabolism are lacking. A model in vitro microsomal-based metabolism assay for rainbow trout (Oncorhynchus mykiss) was utilized to investigate OPE metabolism. Metabolic depletion was only noted for 2 alkyl OPEs and formation of corresponding diester metabolites was low, indicating other unidentified metabolites were formed. Comparison with avian and mammalian models showed fish generally had slower and less complete metabolism, illustrating species-specific differences in biotransformation. Structure also influenced OPE metabolism in that bulky, aryl OPEs were not metabolized. These results provide important information of toxicokinetic processes that can affect the exposure and fate of OPEs in rainbow trout. Chapter 1: General Introduction 1.1 Flame Retardant Chemicals and Organophosphate Esters In today's homes and public spaces, flammability concerns are well warranted. Increased use of plastics, foams, synthetic fiber-base fillings, and electronics bring an increased risk of fire as many of these polymers can be highly flammable. Industry flammability standards, such as California's Technical Bulletin 117, were implemented in an effort to reduce fires and increase average escape time (US EPA, 2007) and, as a result, production and use of flame retardants has become common practice to meet flammability standards in various consumer goods, textiles, furniture, electronics, and plastics.

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1H NMR-based metabolomic analysis of nine organophosphate flame retardants metabolic disturbance in Hep G2 cell line

Cited by 37 publications

References 61 publications

Environmental fate and effects of organophosphate flame retardants in the soil-plant system

Environmental fate and effects of organophosphate flame retardants in the soil-plant system

A Review of a Class of Emerging Contaminants: The Classification, Distribution, Intensity of Consumption, Synthesis Routes, Environmental Effects and Expectation of Pollution Abatement to Organophosphate Flame Retardants (OPFRs)

Metabolism and fate of organophosphate ester (OPE) contaminants in rainbow trout (Oncorhynchus mykiss) using in vitro lab-based studies

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