2020
DOI: 10.21203/rs.3.rs-72159/v1
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2-BFI Attenuates Experimental Autoimmune Encephalomyelitis in Mice via Regulation of Lymphocytes Subsets

Abstract: Background: Imidazoline compounds are well accepted to exhibit various pharmacological effects including antidepressant, anti-inflammatory, analgesic, anti-morphine tolerance and inhibit the activity of monoamine oxidase. 2-(-2-benzofuranyl)-2-imidazoline (2-BFI), a selective imidazoline 2 receptor (I2R) ligand, has been proven to exhibit therapeutic effects for various neuroimmunological diseases. However, the mechanism behind its neuroprotective properties remains elusive. Methods: In this study, we used 2-B… Show more

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