2-Oxazolidinones

Structures of Cycloserine and 2-Oxazolidinone Probed by X-ray Photoelectron Spectroscopy: Theory and Experiment

“…13,17,18 The perimeter of the ring is correctly described within 0.5 to 1.5% for the two compounds, however bond angles show certain discrepancies from the reported crystal structures as a result of the absence of intermolecular and crystal packing forces in the gas phase. Apart from this discrepancy, the overall agreement is good.…”

“…Our second compound, OX2, has been well-studied, 16,17 and OX2 and its derivatives are widely used in the pharmaceutical industry. 17 It is a building block of the active antibacterial agent Linezolid 18 , and its derivatives have powerful catalytic activity in Aldol-type reactions.…”

“…17 It is a building block of the active antibacterial agent Linezolid 18 , and its derivatives have powerful catalytic activity in Aldol-type reactions. 19,20 The X-ray crystal structure of OX2 shows evidence of the presence of intermolecular hydrogen bonding.…”

An efficient access to functionally substituted 1,3-oxazolidin-2-ones via cyclization of 1-alkylamino- and 1-arylamino-3-[2-(vinyloxy)ethoxy)]propan-2-ols with dimethyl carbonate

“…2,3,13,14 Oxazolidin-2-one-containing polymers possess high heat resistance and thermal stability, high elasticity and improved physico-mechanical properties that allow them to be successfully applied as coatings, lacquers, electrically insulating materials, adhesives, foam plastics and so on. 1,[15][16][17][18] Therefore the development of new methods for the synthesis of oxazolidin-2-one derivatives have drawn much attention in recent years.…”

“…[1][2][3] Among oxazolidin-2-ones derivatives there are new synthetic antibacterial agents active against gram-positive microorganisms, including multiple-antibiotic resistant strains (eg. linezolid which has been awarded the 2003 Prix Galien in Germany, as the prominent innovative drug), [4][5][6] as well as pharmaceuticals with different pharmacological activities e.g.…”