2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides

Abstract

Carbon nanotube (CNT) reinforced (0.05–0.5% by wt) polycaprolactone (PCL)‐based composites were prepared by compression molding. Addition of 0.2% CNT caused a 131% improvement of tensile strength (TS) of PCL films. The tensile modulus (TM) and elongation at break (Eb) of PCL were also significantly improved with the addition of CNT. The water vapor permeability of PCL was 1.51 g·mm/m2·day but 0.2% CNT containing PCL films showed 1.08 g·mm/m2·day. Similarly, the oxygen transmission rate (OTR) of PCL films was found to decrease with the addition of CNT. But, carbon dioxide transmission rate (CO2TR) of PCL film was improved due to incorporation of CNT. Effect of gamma radiation on PCL films and CNT reinforced PCL‐based composites were also studied. The TS of the irradiated (10 kGy) PCL films gained to 75% higher than control sample. The TS of the 0.2% CNT reinforced composite film was reached to 41 MPa at 15 kGy dose. The barrier properties of non‐irradiated and irradiated (10 kGy) PCL films and composites (0.2% CNT reinforced) were also measured. Both PCL films and composites showed lower values of WVP upon irradiation and indicated better water vapor barrier. The OTR and CO2TR of the irradiated (10 kGy) PCL films and composites were decreased compared to their counterparts. Surface and interface morphologies of the composites were studied by scanning electron microscopy. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

Prevalence and Responsiveness to Treatment of Lung Abnormalities on Chest Computed Tomography in Patients With Microscopic Polyangiitis: A Multicenter, Longitudinal, Retrospective Study of One Hundred Fifty Consecutive Hospital‐Based Japanese Patients

“…The medical records for the departments of rheumatology, nephrology, neurology, respiratory diseases, and otorhinolaryngology were reviewed. We further identified 180 patients who met the definition of MPA, according to the Chapel Hill Consensus Conference (16,17), with positive ANCAs and/or biopsy-proven small vessel vasculitis.…”

Intravenous Immunoglobulin as an Immunomodulating Agent in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides: A French Nationwide Study of Ninety‐Two Patients

“…We performed a nationwide retrospective multicenter study in patients attending departments of internal medicine, pulmonology, and rheumatology. Patients who received at least 1 course of IVIG and who met the American College of Rheumatology 1990 criteria (13) and/or the European Medicines Agency (EMA) algorithm (14) and/or the definitions from the 2012 Chapel Hill Consensus Conference (15) for GPA, MPA, or eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) were included. Among all of the patients who were included in this study, 22 patients were part of a prospective open-label trial previously conducted by our group (the IVIGs for Relapses of Systemic Vasculitides Associated with ANCA [IGANCA] trial) (10), and we provide additional followup data herein.…”

Vasculitis: do we know more to classify better?

“…Many of these points had already been incorporated in the Ankara 2008 criteria, such as the use of ANCA, magnetic resonance angiography (MRA) and computed tomography angiography (CTA) in the diagnosis [10]. This study also emphasized the need for the development of a classification tree, which was provided by CHCC 2012 [6].…”

“…With the substantial advances in our understanding of vasculitis pathogenesis, in 2012, a second International CHCC was held in order to add important categories of vasculitis not included in the CHCC 1994 nomenclature system [6]. The identification off anti-neutrophil cytoplasmic antibodies (ANCA) in 1982 was a great step forward in our understanding of pathogenesis in at least one group of diseases.…”