Catalysts with the hydrotalcite-like structure and general formula NiCuAlyz-HT having (Ni ? Cu)/Al atomic ratio of 3.0 with varying Ni:Cu atomic compositions (100:0-50:50) were synthesized, characterized and tested for isomerization of eugenol to isoeugenol. The decrease in the activity upon addition of copper to NiAl lattice is investigated through temperature programmed reduction and phenol adsorption.