234 Gossypol, a small molecule inhibitor of BCL-2, increases radiation-induced cytotoxicity in human prostate and head and neck cancer cells

Geldof, Albert A.; Kuipers, Gitta K.; Sminia, Peter; Lafleur, Marie-Judith; Zerp, S.F.; Yangs, D.; Lippmann, Morton; Slotman, Ben J.; Verheij, Marcel

doi:10.1016/s0167-8140(06)80711-5

Radiotherapy and Oncology

2006

DOI: 10.1016/s0167-8140(06)80711-5

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234 Gossypol, a small molecule inhibitor of BCL-2, increases radiation-induced cytotoxicity in human prostate and head and neck cancer cells

Albert A. Geldof¹,

Gitta K. Kuipers²,

Peter Sminia³

et al.

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An improved ultrasound‐assisted extraction process of gossypol acetic acid from cottonseed soapstock

Jia

Zhan

et al. 2009

AIChE Journal

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in Wiley InterScience (www.interscience.wiley.com).To investigate the extracted process of gossypol acetic acid (G-AA) from cottonseed soapstock and explore the improvement of its yield and purity, a novel ultrasoundassisted extraction and crystallization method was introduced to this process. Under the optimized conditions, preliminary G-AA with the yield of 1300 mg and the purity of 95.9% could be obtained from 100 g of fresh soapstock by ultrasound-assisted extraction. In addition, UV, IR, and NMR spectrum further confirmed the detailed chemical structure of G-AA. Assay of inhibiting human prostate tumor cell line PC-3 and human breast cancer cell line MDA-MB-231 revealed its biological activity, the values of IC 50 are 9.096 lmol/L and 14.37 lmol/L respectively. In comparison with the conventional solvent extraction, this novel process increases the content of G-AA over 90%, reduces the time of crystallization by 75%, and retains the anticancer activity of gossypol.

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An improved ultrasound‐assisted extraction process of gossypol acetic acid from cottonseed soapstock

Jia

Zhan

et al. 2009

AIChE Journal

View full text Add to dashboard Cite

show abstract

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234 Gossypol, a small molecule inhibitor of BCL-2, increases radiation-induced cytotoxicity in human prostate and head and neck cancer cells

Cited by 1 publication

References 0 publications

An improved ultrasound‐assisted extraction process of gossypol acetic acid from cottonseed soapstock

An improved ultrasound‐assisted extraction process of gossypol acetic acid from cottonseed soapstock

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