238 When endometrial sampling is not an option, the value of endometrial thickness in predicting endometrial hyperplasia in patients with postmenopausal bleeding

Abstract

breast cancer (81%), 33 patients harbor pathogenic germline mutation or VUS (33%), with the BRCA1 and BRCA2 genes being the most frequently mutated (24% and 15%, respectively). Five years OS was 88% and no statistical difference in the OS was observed in both groups (without mutation 92% and with mutation 76%, p-value=0,138). Fifty-one patients reported having some degree of physical limitation to perform daily activities (41%), with complications of mastectomy being the main cause (62%). Eighteen patients harboring germline mutation stated that the diagnosis helped to change at least one habit of life, such as exercising or having a healthier diet (58%). Most patients had normal depressive scores (67% and 54%, respectively) and no correlation was found between these symptoms and oncological diagnosis (p=0,69 and p=0,75, respectively). Conclusions In this population, oncogenetic counseling did not have a negative impact.